BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase (Q24298631)

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9 January 2020

title

BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase (English)

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9 January 2020

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BRCA1 associated RING domain 1

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positive regulation of apoptotic process

GOA release 2020-03-11

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GOA release 2020-03-11

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1

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9 January 2020

author name string

Charles Edward Jefford

2

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9 January 2020

Philip Berardi

3

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9 January 2020

Jian-Yu Wu

4

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9 January 2020

Laetitia Cartier

5

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9 January 2020

Karl-Heinz Krause

6

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9 January 2020

Irmgard Irminger-Finger

7

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9 January 2020

language of work or name

English

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publication date

1 May 2005

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9 January 2020

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9 January 2020

volume

24

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9 January 2020

issue

23

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9 January 2020

page(s)

3726-3736

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The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

9 January 2020

cites work

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

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BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

21 January 2018

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BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated

21 January 2018

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Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity

21 January 2018

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Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

21 January 2018

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BRCA1-dependent and independent functions of BARD1

21 January 2018

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Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis

21 January 2018

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In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells

21 January 2018

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Mutational analysis of BARD1 in familial breast cancer patients in Japan

21 January 2018

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DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage

21 January 2018

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Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity

21 January 2018

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Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

21 January 2018

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Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

21 January 2018

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Mutation screening of the BARD1 gene: evidence for involvement of the Cys557Ser allele in hereditary susceptibility to breast cancer

21 January 2018

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p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

21 January 2018

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Molecular interaction map of the mammalian cell cycle control and DNA repair systems

21 January 2018

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Regulation of p53 in response to DNA damage

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

21 January 2018

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Tumorigenesis in mice carrying a truncating Brca1 mutation

21 January 2018

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

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Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability

21 January 2018

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p53 Phosphorylation: biochemical and functional consequences

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Prediction of central nervous system embryonal tumour outcome based on gene expression

21 January 2018

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Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

21 January 2018

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Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat.

21 January 2018

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Dissection of signal-regulated transcriptional modules by signaling pathway interference in oncogene-transformed cells

21 January 2018

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

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Genetic steps of mammalian homologous repair with distinct mutagenic consequences

21 January 2018

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Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers

21 January 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

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Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

21 January 2018

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DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.

21 January 2018

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DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

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Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 January 2018

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The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

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Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

21 January 2018

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

21 January 2018

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Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism

21 January 2018

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7 January 2021

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

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7 January 2021

A third-generation lentivirus vector with a conditional packaging system

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7 January 2021

Factors in the causation and incidence of ovarian cancer

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7 January 2021

Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations

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7 January 2021

Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208491

1 reference

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Dimensions Publication ID

9 January 2020

1014528972

0 references

1 reference