Twinkle mtDNA helicase (Q21443395)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

T7-like mitochondrial DNA helicase
TWNK
mitochondrial twinkle protein
T7 helicase-related protein with intramitochondrial nucleoid localization
ataxin 8
twinkle protein, mitochondrial
T7 gp4-like protein with intramitochondrial nucleoid localization
progressive external ophthalmoplegia 1 protein
ATXN8

Language	Label	Description	Also known as
English	Twinkle mtDNA helicase	mammalian protein found in Homo sapiens	T7-like mitochondrial DNA helicase TWNK mitochondrial twinkle protein T7 helicase-related protein with intramitochondrial nucleoid localization ataxin 8 twinkle protein, mitochondrial T7 gp4-like protein with intramitochondrial nucleoid localization progressive external ophthalmoplegia 1 protein ATXN8

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Archaeal primase DnaG/twinkle, TOPRIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA helicase, DnaB-like, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protease binding

determination method or standard

1 reference

8 April 2019

DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

helicase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

single-stranded DNA binding

determination method or standard

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

5'-3' DNA helicase activity

determination method or standard

2 references

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

8 April 2019

TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

mitochondrial matrix

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

mitochondrial nucleoid

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

8 April 2019

The layered structure of human mitochondrial DNA nucleoids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

biological process

mitochondrial transcription

determination method or standard

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

mitochondrion organization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

protein homooligomerization

determination method or standard

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

mitochondrial DNA replication

determination method or standard

3 references

8 April 2019

TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

protein hexamerization

determination method or standard

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

cellular response to glucose stimulus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

DNA unwinding involved in DNA replication

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method or standard

DNA helicase, DnaB-like, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Archaeal primase DnaG/twinkle, TOPRIM domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000309595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000309595

ENSP00000359248

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000359248

ENSP00000494389

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494389

ENSP00000496746

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496746

ENSP00000494326

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494326

ENSP00000496246

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496246

ENSP00000496012

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496012

ENSP00000497629

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497629

0 references

Sitelinks

Wikipedia(2 entries)

cawiki Twinkle
enwiki Twinkle (protein)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21443395&oldid=2023042488"