selectin E (Q4037752)

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mammalian protein found in Homo sapiens

SELE
endothelial adhesion molecule 1
ELAM-1
CD62 antigen-like family member E
LECAM2
E-selectin
endothelial leukocyte adhesion molecule 1
Leukocyte-endothelial cell adhesion molecule 2
leukocyte endothelial cell adhesion molecule 2

Language	Label	Description	Also known as
English	selectin E	mammalian protein found in Homo sapiens	SELE endothelial adhesion molecule 1 ELAM-1 CD62 antigen-like family member E LECAM2 E-selectin endothelial leukocyte adhesion molecule 1 Leukocyte-endothelial cell adhesion molecule 2 leukocyte endothelial cell adhesion molecule 2

Statements

1 reference

13 November 2019

UniProt protein ID

Sushi/SCR/CCP superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

C-type lectin-like/link domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

C-type lectin fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

selectin superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

1 reference

based on heuristic

inferred from protein domain or family

Sushi/SCR/CCP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C-type lectin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

C-type lectin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phospholipase binding

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

oligosaccharide binding

determination method or standard

1 reference

8 April 2019

Higher-affinity oligosaccharide ligands for E-selectin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

carbohydrate binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

sialic acid binding

determination method or standard

1 reference

8 April 2019

Higher-affinity oligosaccharide ligands for E-selectin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

cortical cytoskeleton

determination method or standard

1 reference

8 April 2019

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

8 April 2019

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

clathrin-coated pit

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

extracellular space

determination method or standard

1 reference

8 April 2019

Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

biological process

leukocyte cell-cell adhesion

determination method or standard

1 reference

8 April 2019

Higher-affinity oligosaccharide ligands for E-selectin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

response to interleukin-1

determination method or standard

1 reference

8 April 2019

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

positive regulation of receptor internalization

determination method or standard

1 reference

8 April 2019

Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

actin filament-based process

determination method or standard

1 reference

8 April 2019

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

leukocyte migration involved in inflammatory response

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

activation of phospholipase C activity

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

response to tumor necrosis factor

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

regulation of inflammatory response

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

leukocyte tethering or rolling

determination method or standard

1 reference

8 April 2019

Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

inflammatory response

determination method or standard

1 reference

8 April 2019

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

leukocyte migration

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

calcium-mediated signaling

determination method or standard

1 reference

8 April 2019

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16581

determination method or standard

physically interacts with

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1215923

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3707446

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

sushi/SCR/CCP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

C-type lectin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

C-type lectin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

Selectin, C-type lectin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16581

Identifiers

MeSH descriptor ID

subject named as

E-Selectin

0 references

D12.776.395.550.200.700.300

0 references

D12.776.503.843.300

0 references

D12.776.543.550.200.700.300

0 references

D23.050.301.350.700.300

0 references

D09.400.430.890.200.700.300

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000331736

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000331736

ENSP00000356748

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356748

ENSP00000356749

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356749

ENSP00000356750

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356750

ENSP00000356751

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356751

ENSP00000476784

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476784

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(12 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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