Membrane metalloendopeptidase (Q414232)

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mammalian protein found in Homo sapiens
  • CALLA
  • Neutral endopeptidase
  • neprilysin
  • skin fibroblast elastase
  • membrane metallo-endopeptidase variant 2
  • neprilysin-390
  • common acute lymphocytic leukemia antigen
  • neprilysin-411
  • neutral endopeptidase 24.11
  • SFE
  • atriopeptidase
  • membrane metallo-endopeptidase variant 1
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
  • NEP
  • MME
  • Enkephalinase
edit
Language Label Description Also known as
English
Membrane metalloendopeptidase
mammalian protein found in Homo sapiens
  • CALLA
  • Neutral endopeptidase
  • neprilysin
  • skin fibroblast elastase
  • membrane metallo-endopeptidase variant 2
  • neprilysin-390
  • common acute lymphocytic leukemia antigen
  • neprilysin-411
  • neutral endopeptidase 24.11
  • SFE
  • atriopeptidase
  • membrane metallo-endopeptidase variant 1
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
  • NEP
  • MME
  • Enkephalinase

Statements

molecular function
endopeptidase activity
determination method or standard
IDA
IGI
IMP
9 references
retrieved
8 April 2019
stated in
Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IMP
retrieved
8 April 2019
stated in
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IMP
retrieved
8 April 2019
stated in
A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IMP
retrieved
8 April 2019
stated in
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IGI
retrieved
8 April 2019
stated in
Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
cell component
biological process
proteolysis
determination method or standard
IDA
IEA
6 references
retrieved
3 January 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IEA
retrieved
3 January 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IEA
retrieved
3 January 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IEA
retrieved
3 January 2017
stated in
Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IDA
retrieved
3 January 2017
stated in
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IDA
retrieved
3 January 2017
stated in
Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473
determination method or standard
IDA
proteolysis
determination method or standard
IDA
IEA
IGI
IMP
12 references
retrieved
8 April 2019
stated in
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IMP
retrieved
8 April 2019
stated in
A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IMP
retrieved
8 April 2019
stated in
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IEA
retrieved
8 April 2019
stated in
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses
GOA
curator
UniProt
UniProt protein ID
P08473
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
retrieved
8 April 2019
stated in
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473
determination method or standard
IDA
Gene Atlas image
PBB GE MME 203434 s at fs.png
732 × 530; 10 KB
0 references

Identifiers

 
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