microtubule associated protein tau (Q419507)

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mammalian protein found in Homo sapiens
  • PHF-tau
  • microtubule-associated protein tau
  • neurofibrillary tangle protein
  • tau proteins
  • protein phosphatase 1, regulatory subunit 103
  • paired helical filament-tau
  • G protein beta1/gamma2 subunit-interacting factor 1
  • MAPT
  • tau protein
edit
Language Label Description Also known as
English
microtubule associated protein tau
mammalian protein found in Homo sapiens
  • PHF-tau
  • microtubule-associated protein tau
  • neurofibrillary tangle protein
  • tau proteins
  • protein phosphatase 1, regulatory subunit 103
  • paired helical filament-tau
  • G protein beta1/gamma2 subunit-interacting factor 1
  • MAPT
  • tau protein

Statements

has effect
tauopathy
0 references
molecular function
protein binding
determination method or standard
IPI
27 references
retrieved
1 January 2018
stated in
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tau promoter confers neuronal specificity and binds Sp1 and AP-2
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Akt and CHIP coregulate tau degradation through coordinated interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Impact of the cellular prion protein on amyloid-β and 3PO-tau processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
GOA
curator
Alzheimers Project at University of Toronto
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains
GOA
curator
Alzheimers Project at University of Toronto
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IPI
microtubule binding
determination method or standard
IBA
IDA
IEA
IMP
NAS
TAS
8 references
retrieved
1 January 2018
stated in
The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
TAS
retrieved
1 January 2018
stated in
Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
TAS
retrieved
1 January 2018
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
NAS
retrieved
1 January 2018
stated in
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IEA
retrieved
1 January 2018
stated in
Tau protein binds to microtubules through a flexible array of distributed weak sites
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IBA
cell component
cytoplasm
determination method or standard
IDA
IEA
IMP
ISS
5 references
retrieved
1 January 2018
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
ISS
retrieved
1 January 2018
stated in
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IEA
retrieved
1 January 2018
stated in
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
plasma membrane
determination method or standard
IDA
IEA
TAS
5 references
retrieved
1 January 2018
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IEA
retrieved
1 January 2018
stated in
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
GOA
curator
UniProt
UniProt protein ID
P10636
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
microtubule cytoskeleton
determination method or standard
IDA
NAS
5 references
retrieved
1 January 2018
stated in
The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
NAS
retrieved
1 January 2018
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
NAS
retrieved
1 January 2018
stated in
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Surface-decoration of microtubules by human tau
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
retrieved
1 January 2018
stated in
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636
determination method or standard
IDA
biological process
Gene Atlas image
PBB GE MAPT 203929 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D016875
subject named as
tau Proteins
0 references
RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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