Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46, AftA, Rv3792) is an enzyme with systematic name galactofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 5-O-alpha-D-arabinofuranosyltransferase.[1] This enzyme catalyses the following chemical reaction
| Galactan 5-O-arabinofuranosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.46 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-β-D-arabinofuranose at the 5-O-position of the eighth, tenth and twelfth galactofuranose unit of the galactofuranan chain of [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
This enzyme is isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum.
References
edit- ^ Alderwick LJ, Seidel M, Sahm H, Besra GS, Eggeling L (June 2006). "Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis". The Journal of Biological Chemistry. 281 (23): 15653–61. doi:10.1074/jbc.M600045200. PMID 16595677.
External links
edit- Galactan+5-O-arabinofuranosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
