Santosham or Santhosham may refer to:
- Santosham (1955 film), an Indian Telugu-language film starring N. T. Rama Rao
- Santhosham (1998 film), an Indian Tamil-language film starring Saravanan and Suvalakshmi
- Santosham (2002 film), an Indian Telugu-language film starring Akkineni Nagarjuna and Shriya Saran
- Santhosham (2023 film), an Indian Malayalam-language film starring Amith Chakalakkal and Anu Sithara