Site-specific DNA-methyltransferase (cytosine-N4-specific) (EC 2.1.1.113, modification methylase, restriction-modification system, DNA[cytosine-N4]methyltransferase, m4C-forming MTase, S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction:
| Site-specific DNA-methyltransferase (cytosine-N4-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.113 | ||||||||
| CAS no. | 169592-50-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + DNA cytosine S-adenosyl-L-homocysteine + DNA N4-methylcytosine
This is a large group of enzymes.[5]
See also
editReferences
edit- ^ Kessler C, Manta V (August 1990). "Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3)". Gene. 92 (1–2): 1–248. doi:10.1016/0378-1119(90)90486-B. PMID 2172084.
- ^ Klimasauskas S, Timinskas A, Menkevicius S, Butkienè D, Butkus V, Janulaitis A (December 1989). "Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases". Nucleic Acids Research. 17 (23): 9823–32. doi:10.1093/nar/17.23.9823. PMC 335216. PMID 2690010.
- ^ Roberts RJ (April 1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Research. 18 Suppl: 2331–65. doi:10.1093/nar/18.suppl.2331. PMC 331877. PMID 2159140.
- ^ Yuan R (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annual Review of Biochemistry. 50: 285–319. doi:10.1146/annurev.bi.50.070181.001441. PMID 6267988.
- ^ Roberts RJ. "A complete listing of all of these enzymes". The Restriction Enzyme Database.
External links
edit- Site-specific+DNA-methyltransferase+(cytosine-N4-specific) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
