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EPHA6

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EPHA6
Identifiers
AliasesEPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDsOMIM: 600066; MGI: 108034; HomoloGene: 56396; GeneCards: EPHA6; OMA:EPHA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080448
NM_001278300
NM_001278301
NM_173655

NM_007938

RefSeq (protein)

NP_001073917
NP_001265229
NP_001265230
NP_775926

NP_031964

Location (UCSC)Chr 3: 96.81 – 97.76 MbChr 16: 59.47 – 60.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.[5][6]

EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080224Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055540Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
  6. ^ "Entrez Gene: EPHA6 EPH receptor A6".
  7. ^ Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer". Oncology Letters. 15 (4): 5257–5263. doi:10.3892/ol.2018.7919. PMC 5840743. PMID 29552165.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q62413 (Mouse Ephrin type-A receptor 6) at the PDBe-KB.