Natalie Strynadka
Natalie Strynadka | |
|---|---|
 Strynadka in 2015 | |
| Born | 1963 (age 60–61) |
| Alma mater | University of Alberta |
| Awards |
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| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | Probing molecular interactions at various levels of structural definition (1990) |
| Doctoral advisor | Michael N. G. James[6] |
| Website | |
Natalie C. J. Strynadka is a Canadian biochemist who is a professor[7][8] of Biochemistry in the Department of Biochemistry and Molecular Biology at the University of British Columbia.[9][10][11][12][13]
Education
[edit]Strynadka was educated at the University of Alberta where she was awarded a PhD in 1990.[14] Her thesis committee included Michael N. G. James and Sir David Chilton Phillips.[14]
Awards and honours
[edit]Strynadka was elected a Fellow of the Royal Society (FRS) in 2015. Her certificate of election reads:[1]
Natalie Strynadka is a pioneer in the study of proteins and protein assemblies essential to bacterial pathogenicity and antibiotic resistance. Her agenda-setting dissection of the membrane assemblies involved in infection, virulence and bacterial cell wall synthesis is having major impact in the development of therapeutic agents; both antibiotics and vaccines.
References
[edit]- ^ a b Anon (2015). "Professor Natalie Strynadka FRS". London: royalsociety.org. Archived from the original on 12 May 2015.
- ^ Lovering, A. L.; De Castro, L. H.; Lim, D; Strynadka, N. C. (2007). "Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis". Science. 315 (5817): 1402–5. Bibcode:2007Sci...315.1402L. doi:10.1126/science.1136611. PMID 17347437. S2CID 41658295.
- ^ Wilke, M. S.; Heller, M; Creagh, A. L.; Haynes, C. A.; McIntosh, L. P.; Poole, K; Strynadka, N. C. (2008). "The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR". Proceedings of the National Academy of Sciences. 105 (39): 14832–7. Bibcode:2008PNAS..10514832W. doi:10.1073/pnas.0805489105. PMC 2567453. PMID 18812515.
- ^ Strynadka, N. C.; Jensen, S. E.; Johns, K; Blanchard, H; Page, M; Matagne, A; Frère, J. M.; James, M. N. (1994). "Structural and kinetic characterization of a beta-lactamase-inhibitor protein". Nature. 368 (6472): 657–60. Bibcode:1994Natur.368..657S. doi:10.1038/368657a0. PMID 8145854. S2CID 25485212.
- ^ King, A. M.; Reid-Yu, S. A.; Wang, W; King, D. T.; De Pascale, G; Strynadka, N. C.; Walsh, T. R.; Coombes, B. K.; Wright, G. D. (2014). "Aspergillomarasmine a overcomes metallo-β-lactamase antibiotic resistance". Nature. 510 (7506): 503–6. Bibcode:2014Natur.510..503K. doi:10.1038/nature13445. PMC 4981499. PMID 24965651.
- ^ Strynadka, N. C. J.; James, M. N. G. (1989). "Crystal Structures of the Helix-Loop-Helix Calcium-Binding Proteins". Annual Review of Biochemistry. 58: 951–98. doi:10.1146/annurev.bi.58.070189.004511. PMID 2673026.
- ^ "Strynadka laboratory". strynadkalab.biochem.ubc.ca. Archived from the original on 12 August 2015.
- ^ "Natalie C.J. Strynadka, PhD: Senior International Research Scholar / 2012–Present". hhmi.org. Archived from the original on 18 May 2015.
- ^ Strynadka, N. C.; Adachi, H; Jensen, S. E.; Johns, K; Sielecki, A; Betzel, C; Sutoh, K; James, M. N. (1992). "Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 a resolution". Nature. 359 (6397): 700–5. Bibcode:1992Natur.359..700S. doi:10.1038/359700a0. PMID 1436034. S2CID 4253788.
- ^ Paetzel, M; Karla, A; Strynadka, N. C.; Dalbey, R. E. (2002). "Signal peptidases". Chemical Reviews. 102 (12): 4549–80. doi:10.1021/cr010166y. PMID 12475201.
- ^ Gao, S; Kinzig, K. P.; Aja, S; Scott, K. A.; Keung, W; Kelly, S; Strynadka, K; Chohnan, S; Smith, W. W.; Tamashiro, K. L.; Ladenheim, E. E.; Ronnett, G. V.; Tu, Y; Birnbaum, M. J.; Lopaschuk, G. D.; Moran, T. H. (2007). "Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake". Proceedings of the National Academy of Sciences. 104 (44): 17358–63. doi:10.1073/pnas.0708385104. PMC 2077261. PMID 17956983.
- ^ Zarivach, R; Deng, W; Vuckovic, M; Felise, H. B.; Nguyen, H. V.; Miller, S. I.; Finlay, B. B.; Strynadka, N. C. (2008). "Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS". Nature. 453 (7191): 124–7. Bibcode:2008Natur.453..124Z. doi:10.1038/nature06832. PMID 18451864. S2CID 205212689.
- ^ Natalie Strynadka publications indexed by the Scopus bibliographic database. (subscription required)
- ^ a b Strynadka, Natalie C. J. (1990). Probing molecular interactions at various levels of structural definition (PhD thesis). University of Alberta. doi:10.7939/R37D2QG6S. OCLC 70312424. ProQuest 230755977.
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