Talk:Cholesterol

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No Physical Properties or Characteristics provided

Like normal form, specific gravity, ability to withstand heat, melting and boiling points, breakdown temperatures, etc. — Preceding unsigned comment added by 2409:4071:220D:7281:3CD0:68FF:FE7F:8333 (talk) 12:09, 17 March 2024 (UTC)[reply]

What about this research?

LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

Link: https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391 Nemohuman (talk) 08:35, 10 March 2024 (UTC)[reply]

Blatant pseudoscience. The authors of the paper work for the THINCS organization. The same authors published another review which has been discredited [1], [2], [3]. They basically argue that elderly people with lower LDL-c have an increased mortality risk. This isn't a controversial finding it is well known, it's because the elderly people studied have increased risk of chronic disease like cancer and this is known to lower cholesterol. It is a case of reverse causality. It is not evidence that high LDL-c is beneficial for health. There is strong evidence that LDL-c causes cardiovascular disease [4]. Psychologist Guy (talk) 16:45, 10 March 2024 (UTC)[reply]

Biosynthesis to be contracted

I propose to remove most of the biosynthesis section, which begins with very early, almost generic steps. Instead the biosynthesis can begin with lanosterol.--Smokefoot (talk) 14:37, 13 August 2024 (UTC)[reply]

the claim "Biosynthesis in all cells" to be deleted

In multiple location the page claims that cholesterol is made in all cells, but there is no citation. Furthermore, it is well accepted that neurons do not make cholesterol. And almost all studies show that cholesterol is transported in the blood and then taken up into cells through receptor mediated endocytosis. The mere presence of the enzymes that metabolize cholesterol is not evidence that the cells make cholesterol. Advocates for ubiqitous cholesterol synthesis need to produce evidence that the cholesterol is actually produced in the various cell types rather than taken up.

Lastly, given the large amounts of cholesterol that are taken up by cells from the blood. Some rational as to why the cells would be making cholesterol when there enormous quantities made available every day in the blood needs to be addressed. The data suggests most cells in the body don't make appreciable amounts of cholesterol and the uptake of the cholesterol from the blood or astrocytes dictates the important biological function of cholesterol, not individual cellular synthesis. If there is a biological process known, in a non-hepatic cell, where individual cellular synthesis drives a biological function, please indicate. All the known biological functions of cholesterol, including cholesterol related diseases, is driven by uptake from the blood not synthesis within the affected cells. — Preceding unsigned comment added by PhD2005 (talk • contribs) 03:43, 21 October 2024 (UTC)[reply]