Talk:Orellanine

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LD50

I added LD50 data, and a tiny bit of primary research: according to the literature, the LD50 of Cortinarius Speciocissimus and Orellanus mushrooms is 3 and 2 (freeze-dried) g/kg in mice. This would correspond to 30 and 20 g/kg for fresh mushrooms: more than 1 kg for an adult human. Only few mushroom hunters would eat their catch in such amounts, from which I conclude that either humans are more sensitive than mice, or it often takes more than 2 weeks to kill. I don't have enough background in toxicology to judge this. Han-Kwang 23:18, 6 July 2006 (UTC)[reply]

The LD50 of pure Orellanine in mice is LD50 = 12.5 mg/kg intraperitoneally and LD50 = 90 mg/kg orally. I don't see any data on how much a adult human can ingest, but by reading incidents about Cortinarius poisoning it is obviously significantly less than 2kg. Most poisonings occur when a cortinarius mushroom has been accidently intermixed with other mushrooms and then ingested.

The toxins latency time is extremely long regardless of the amount ingested it seems, in mice that were administered several times ld50 they still had a latency time > 2 days (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7195467&dopt=Citation). mic 01:00, 7 July 2006 (UTC)[reply]

How is there no antidote? What about antioxidants? -lysdexia 02:47, 5 March 2007 (UTC)

There is no direct antidote because the toxin, and how it works, is not completely understood. The anti-oxidant, like many other therapies, may help the body recover from the damage caused by the toxin but they don't counteract the poison. ([1] and [2])

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Structure

There is a double bond missing in the right-hand tautomer, the there should be two single-headed arrows instead of one double-headed arrow (which indicates resonance, not tautomerism)