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Thomas A. Rando

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Thomas A. Rando
Born1957[1]
Brooklyn, NY
Academic background
Alma materHarvard College
Harvard Medical School
Academic work
DisciplineNeurology, stem cell biology, biology of aging, regenerative medicine, tissue engineering
InstitutionsStanford University School of Medicine

Thomas A. Rando is an American stem cell biologist and neurologist, best known for his research on basic mechanisms of stem cell biology and the biology of aging. He is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and a professor of Neurology and Molecular, Cell and Developmental Biology at the University of California, Los Angeles.[2] Prior to joining the UCLA faculty, he served as Professor of Neurology and Neurological Sciences at Stanford University School of Medicine, where he was also founding director of the Glenn Center for the Biology of Aging.[3] His additional roles while at Stanford included co-founder and deputy director of the Stanford Center on Longevity, founding director of Stanford's Muscular Dystrophy Association Clinic, and Chief of Neurology at the VA Palo Alto Health Care System.[4][5][6]

Biography

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Rando was born in Brooklyn, New York,[1] and grew up in Maine.[7] He earned a bachelor's degree from Harvard College in biochemistry in 1979, and an MD from Harvard Medical School and PhD in cell and developmental biology from Harvard University in 1987.[6][7][8] He interned at Massachusetts General Hospital and completed his residency in neurology at the University of California, San Francisco.[9] He joined Stanford's Department of Molecular Pharmacology as a research fellow in 1991, and joined Stanford's medical school faculty in 1995.[8] He relocated to Los Angeles to join the UCLA faculty in 2021.[10] Rando is also a founder of Fountain Therapeutics.[11]

Research

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Rando's research on stem cells has addressed how stem cells in tissues throughout the body maintain their potency to participate in tissue homeostasis and tissue repair throughout the life of an organism.[12][13][14] Through these studies, his laboratory has explored the basic mechanisms by which stem cells maintain a dormant, or "quiescent" state, when not engage in generation of new tissue.[15][16][17] They have demonstrated how the depth of stem cell quiescence influences the potency of those cells to participate in tissue repair and regeneration.[18] These findings have led to advances in studies of stem cell therapeutics in the broader field of regenerative medicine.[19]

In 2005, Rando's laboratory was the first to use the technique of heterochronic parabiosis to explore the effects of the systemic circulation on stem cell function.[20][21][22] Rando's group has pioneered studies of the epigenetics of stem cell aging, exploring the role of "epigenetic rejuvenation" as an explanation for the paradigm-shifting findings of heterochronic parabiosis.[23][24] These studies have revealed how exercise itself can lead to rejuvenation of aged stem cells.[25] Their studies focus on physiologic, pharmacologic, genetic, and dietary interventions to reverse cellular aging and to produce therapies for aging-related diseases.[26][27][28]

Rando's research interests also include muscular dystrophies, tissue engineering, and regenerative rehabilitation.[14][29][30][31][32]

Honors

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References

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  1. ^ a b "Rejuvenecer nuestras células puede hacerlas más proclives al cáncer". El Pais. 14 May 2018. Retrieved 28 July 2021.
  2. ^ "Thomas A. Rando, MD, PhD". Regenerative Medicine at the McGowan Institute. Retrieved 2022-09-28.
  3. ^ "Stanford Lands $5M Grant". San Francisco Business Times. 22 February 2011. Retrieved 28 July 2021.
  4. ^ "Thomas Rando named director of UCLA Broad Stem Cell Research Center". UCLA. Retrieved 2022-09-28.
  5. ^ "People at the Stanford Center on Longevity". longevity.stanford.edu. Retrieved 2020-06-30.
  6. ^ a b "Profile". stanford.edu. Retrieved 28 July 2021.
  7. ^ a b "Rando to head geriatric center at Palo Alto VA". Stanford News. 24 May 2000. Retrieved 28 July 2021.
  8. ^ a b c "Promotions announced for two School of Medicine faculty members". Stanford News. 4 December 2002. Retrieved 28 July 2021.
  9. ^ "Dr. Thomas Rando Elected to National Academy of Medicine". mirm-pitt.net. 18 November 2016. Retrieved 28 July 2021.
  10. ^ "Thomas Rando named director of UCLA Broad Stem Cell Research Center". UCLA. Retrieved 2022-09-28.
  11. ^ "Fountain Therapeutics Closes $6 Million Series A-1 Financing". mirm-pitt.net. 3 June 2020. Retrieved 28 July 2021.
  12. ^ "Stem cells, ageing and the quest for immortality". Nature. 28 June 2006. Retrieved 30 July 2021.
  13. ^ Goodell, Margaret A.; Rando, Thomas A. (4 December 2015). "Stem cells and healthy aging". Science. 350 (6265): 1199–1204. Bibcode:2015Sci...350.1199G. doi:10.1126/science.aab3388. PMID 26785478. S2CID 29472696. Retrieved 30 July 2021.
  14. ^ a b "Stem cell therapy for muscular dystrophies". The Journal of Clinical Investigation. 18 September 2020. Retrieved 30 July 2021.
  15. ^ Bjornson, Christopher R. R.; Cheung, Tom H.; Liu, Ling; Tripathi, Pinky V.; Steeper, Katherine M.; Rando, Thomas A. (2012). "Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells". Stem Cells. 30 (2): 232–242. doi:10.1002/stem.773. ISSN 1549-4918. PMC 3384696. PMID 22045613.
  16. ^ Cheung, Tom H.; Quach, Navaline L.; Charville, Gregory W.; Liu, Ling; Park, Lidia; Edalati, Abdolhossein; Yoo, Bryan; Hoang, Phuong; Rando, Thomas A. (February 2012). "Maintenance of muscle stem-cell quiescence by microRNA-489". Nature. 482 (7386): 524–528. Bibcode:2012Natur.482..524C. doi:10.1038/nature10834. ISSN 0028-0836. PMC 3292200. PMID 22358842.
  17. ^ "Molecular regulation of stem cell quiescence". Nature Reviews Molecular Cell Biology. 23 May 2013. Retrieved 30 July 2021.
  18. ^ Rodgers, Joseph T.; King, Katherine Y.; Brett, Jamie O.; Cromie, Melinda J.; Charville, Gregory W.; Maguire, Katie K.; Brunson, Christopher; Mastey, Namrata; Liu, Ling; Tsai, Chang-Ru; Goodell, Margaret A. (2014-06-19). "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert". Nature. 510 (7505): 393–396. Bibcode:2014Natur.510..393R. doi:10.1038/nature13255. ISSN 0028-0836. PMC 4065227. PMID 24870234.
  19. ^ Quarta, Marco; Cromie, Melinda; Chacon, Robert; Blonigan, Justin; Garcia, Victor; Akimenko, Igor; Hamer, Mark; Paine, Patrick; Stok, Merel; Shrager, Joseph B.; Rando, Thomas A. (20 June 2017). "Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss". Nature Communications. 8: 15613. Bibcode:2017NatCo...815613Q. doi:10.1038/ncomms15613. ISSN 2041-1723. PMC 5481841. PMID 28631758.
  20. ^ Toledano, Hila (2014-04-06). "Faculty Opinions recommendation of Rejuvenation of aged progenitor cells by exposure to a young systemic environment". doi:10.3410/f.1024195.793493221. {{cite journal}}: Cite journal requires |journal= (help)
  21. ^ Brack, Andrew S.; Conboy, Michael J.; Roy, Sudeep; Lee, Mark; Kuo, Calvin J.; Keller, Charles; Rando, Thomas A. (2007-08-10). "Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis". Science. 317 (5839): 807–810. Bibcode:2007Sci...317..807B. doi:10.1126/science.1144090. ISSN 0036-8075. PMID 17690295. S2CID 6767424.
  22. ^ "Healthy aging – it's still all about diet and exercise. For now". Longevity Technology. 31 August 2020. Retrieved 30 July 2021.
  23. ^ Rando, Thomas A.; Chang, Howard Y. (2012-01-20). "Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock". Cell. 148 (1): 46–57. doi:10.1016/j.cell.2012.01.003. ISSN 0092-8674. PMC 3336960. PMID 22265401.
  24. ^ Sarkar, Tapash Jay; Quarta, Marco; Mukherjee, Shravani; Colville, Alex; Paine, Patrick; Doan, Linda; Tran, Christopher M.; Chu, Constance R.; Horvath, Steve; Qi, Lei S.; Bhutani, Nidhi (2020-03-24). "Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells". Nature Communications. 11 (1): 1545. Bibcode:2020NatCo..11.1545S. doi:10.1038/s41467-020-15174-3. ISSN 2041-1723. PMC 7093390. PMID 32210226.
  25. ^ Brett, Jamie O.; Arjona, Marina; Ikeda, Mika; Quarta, Marco; de Morrée, Antoine; Egner, Ingrid M.; Perandini, Luiz A.; Ishak, Heather D.; Goshayeshi, Armon; Benjamin, Daniel I.; Both, Pieter (April 2020). "Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1". Nature Metabolism. 2 (4): 307–317. doi:10.1038/s42255-020-0190-0. ISSN 2522-5812. PMC 7323974. PMID 32601609.
  26. ^ "Turning Back the Clock on Aging Cells". The New York Times. 24 March 2020. Retrieved 30 July 2021.
  27. ^ "Old human cells rejuvenated with stem cell technology". Science Daily. 24 March 2020. Retrieved 30 July 2021.
  28. ^ "Asynchronous, contagious and digital aging". Nature Aging. 14 January 2021. Retrieved 30 July 2021.
  29. ^ Maguire, Katie K.; Lim, Leland; Speedy, Sedona; Rando, Thomas A. (May 2013). "Assessment of disease activity in muscular dystrophies by noninvasive imaging". The Journal of Clinical Investigation. 123 (5): 2298–2305. doi:10.1172/JCI68458. ISSN 1558-8238. PMC 3638910. PMID 23619364.
  30. ^ "Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research". Science Daily. 24 April 2013. Retrieved 30 July 2021.
  31. ^ "An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy". Nature Biotechnology. 30 May 2016. Retrieved 30 July 2021.
  32. ^ "Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics". Cell Stem Cell. 1 March 2018. Retrieved 30 July 2021.
  33. ^ "Three at Stanford win NIH awards, funding". San Francisco Business Times. 29 September 2005. Retrieved 30 July 2021.
  34. ^ "Board Member in the News: Thomas Rando elected to the American Academy of Arts and Sciences". AFAR. 6 May 2020. Retrieved 30 July 2021.
  35. ^ "Stanford scientists awarded grants for innovative research". Stanford Medicine. 30 September 2013. Retrieved 30 July 2021.
  36. ^ "2015 AAAS Fellows Recognized for Contributions to Advancing Science". American Association for the Advancement of Science. Retrieved 2020-06-30.
  37. ^ "Class of 2016". National Academy of Medicine. Retrieved 2020-06-30.
  38. ^ "New Members". American Academy of Arts & Sciences. Retrieved 2020-06-30.
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