Neuromedin B

neuromedin B
Identifikatori
Simbol	NMB
Entrez	4828
HUGO	7842
OMIM	162340
RefSeq	NM_021077
UniProt	P08949
Drugi podaci
Lokus	Hromozom 15 q11-qter

Neuromedin B (NMB) je bombesinu srodan peptid kod sisara.^[1]^[2] On je originalno bio izdvojen iz svinjske kičmene moždine, i kasnije je pokazano da je prisutan u humanom humanom nervnom sistemu i gastrointestinalnom traktu.^[3]

Sekvenca

Sekvenca C-terminalnog dekapeptida je visoko očuvana među sisarskim vrstama: GNLWATGHFM-(NH2). Taj peptid je poznat kao neuromein B, mada je precizniji naziv neuromedin B 23-32. Sekvenca neuromedina B (kod pacova) je: TPFSWDLPEPRSRASKIRVHPRGNLWATGHFM-(NH2).^[4]

Funkcija

Neuromedin reguliše sledeće funkcije:

Literatura

↑ Ohki-Hamazaki H (October 2000). „Neuromedin B”. Prog. Neurobiol. 62 (3): 297–312. DOI:10.1016/S0301-0082(00)00004-6. PMID 10840151.
↑ Jensen RT, Battey JF, Spindel ER, Benya RV (March 2008). „International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states”. Pharmacol. Rev. 60 (1): 1–42. DOI:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.
↑ Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER (1988-09-15). „Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin”. J. Biol. Chem. 263 (26): 13317–23. PMID 2458345. ^{[mrtav link]}
↑ Wada E, Way J, Lebacq-Verheyden AM, Battey JF (1990-09-01). „Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system”. J. Neurosci. 10 (9): 2917–30. PMID 2398368.

Spoljašnje veze

MeSH Neuromedin+B

[pmid10840151-1] Ohki-Hamazaki H (October 2000). „Neuromedin B”. Prog. Neurobiol. 62 (3): 297–312. DOI:10.1016/S0301-0082(00)00004-6. PMID 10840151.

[pmid18055507-2] Jensen RT, Battey JF, Spindel ER, Benya RV (March 2008). „International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states”. Pharmacol. Rev. 60 (1): 1–42. DOI:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

[pmid2458345-3] Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER (1988-09-15). „Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin”. J. Biol. Chem. 263 (26): 13317–23. PMID 2458345. ^{[mrtav link]}

[pmid2398368-4] Wada E, Way J, Lebacq-Verheyden AM, Battey JF (1990-09-01). „Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system”. J. Neurosci. 10 (9): 2917–30. PMID 2398368.

[1]

[2]

[3]

[4]