AM-919
(IUPAC ) ime
(6S,6aR,9R,10aR)-9-(hidroksimetil)-6-
Klinički podaci
Identifikatori
ATC kod
?
PubChem [ 1] [ 2] 10741414
ChemSpider [ 3] 8916745
ChEMBL [ 4] CHEMBL121118 Y
Hemijski podaci
Formula
C 27 H 44 O 4
Mol. masa
432,634 g/mol
SMILES
eMolekuli PubHem
InChI InChI=1S/C27H44O4/c1-5-6-7-8-12-26(2,3)20-16-23(30)25-21-15-19(18-29)10-11-22(21)27(4,13-9-14-28)31-24(25)17-20/h16-17,19,21-22,28-30H,5-15,18H2,1-4H3/t19-,21-,22-,27+/m1/s1 Y Y
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
AM-919 je analgetik koji je kanabinoidni agonist . On je derivat HU-210 koji je supstituisan sa 6β-(3-hidroksipropil) grupom. To dodaje "južnu" alifatičnu hidroksilnu grupu na molekul, tako da je AM-919 hibridna struktura između klasičnih i neklasičnih kanabinoidnih familija.[ 5]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X
Šablon:Kanabinoidi
