CGS-21680

CGS-21680
	3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(etilkarbamoil)-3,4-dihidroksi-oksolan-2-il]purin-2-il]amino]etil]fenil]propanska kiselina
Drugi nazivi	CGS 21680
Identifikacija
CAS registarski broj	120225-54-9
PubChem	3086599
ChemSpider	2343185
ChEMBL	CHEMBL331372
IUPHAR ligand	375
Jmol-3D slike	Slika 1
SMILES
	O=C(O)CCc1ccc(cc1)CCNc2nc(c3ncn(c3n2)[C@@H]4O[C@H](C(=O)NCC)[C@@H](O)[C@H]4O)N
InChI
	InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1 ; Kod: PAOANWZGLPPROA-RQXXJAGISA-N InChI=1/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1; Kod: PAOANWZGLPPROA-RQXXJAGIBL
Svojstva
Molekulska formula	C23H29N7O6
Molarna masa	499,52
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

CGS-21680 je agonist specifičan za adenozinski A_2A tip receptora. On je obično prisutan kao organska hidrohloridna so molekulske težine 536,0 g/M. On je rastvoran do 3,4 mg/mL u DMSO-u, i 20 mg/mL u 45% aq 2-hidroksipropil-β-ciklodekstrin.

Ovaj materijal se koristi za istraživanje neuronske transmisije. To obuhvata istraživanja respiracije gde A_2A receptori učestvuju u generaciji ritma.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Literatura

Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). „Adenosine A_2A receptors mediate GABAergic inhibition of respiration in immature rats”. J Appl Physiol 100 (1): 91–97. DOI:10.1152/japplphysiol.00459.2005. PMID 16141383.
Xie S, Shafer G, Wilson CG, Martin HB (2006). „In vitro adenosine detection with a diamond-based sensor”. Dia Rel Mater 15 (2-3): 225–228. DOI:10.1016/j.diamond.2005.08.018.

Povezano

Adenozinski receptor

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

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