OR2H2
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| Olfaktorni receptor, familija 2, potfamilija H, član 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OR2H2; FAT11; OLFR2; OLFR42B; OR2H3; dJ271M21.2; hs6M1-12 | ||||||||||
| Vanjski ID | OMIM: 600578 MGI: 2177473 HomoloGene: 68546 GeneCards: OR2H2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7932 | 258469 | |||||||||
| Ensembl | ENSG00000204657 | ENSMUSG00000056600 | |||||||||
| UniProt | O95918 | Q0VEL5 | |||||||||
| RefSeq (mRNA) | NM_007160.3 | NM_146477.2 | |||||||||
| RefSeq (protein) | NP_009091.3 | NP_666688.2 | |||||||||
| Lokacija (UCSC) | Chr 6: 29.56 - 29.56 Mb | Chr 17: 37.09 - 37.09 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 2H2 je protein koji je kod ljudi kodiran OR2H2 genom.[1]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]
- Fan W, Liu YC, Parimoo S, Weissman SM (1995). „Olfactory receptor-like genes are located in the human major histocompatibility complex.”. Genomics 27 (1): 119–23. DOI:10.1006/geno.1995.1013. PMID 7665158.
- Fan W, Cai W, Parimoo S, et al. (1996). „Identification of seven new human MHC class I region genes around the HLA-F locus.”. Immunogenetics 44 (2): 97–103. DOI:10.1007/BF02660056. PMID 8662070.
- Eklund AC, Belchak MM, Lapidos K, et al. (2000). „Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites.”. Hum. Immunol. 61 (7): 711–7. DOI:10.1016/S0198-8859(00)00132-4. PMID 10880742.
- Younger RM, Amadou C, Bethel G, et al. (2001). „Characterization of clustered MHC-linked olfactory receptor genes in human and mouse.”. Genome Res. 11 (4): 519–30. DOI:10.1101/gr.160301. PMC 311051. PMID 11282967.
- Fuchs T, Malecova B, Linhart C, et al. (2003). „DEFOG: a practical scheme for deciphering families of genes.”. Genomics 80 (3): 295–302. DOI:10.1006/geno.2002.6830. PMID 12213199.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Volz A, Ehlers A, Younger R, et al. (2003). „Complex transcription and splicing of odorant receptor genes.”. J. Biol. Chem. 278 (22): 19691–701. DOI:10.1074/jbc.M212424200. PMID 12637542.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family.”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. DOI:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). „Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.”. Immunogenetics. 62 (9): 569–84. DOI:10.1007/s00251-010-0468-6. PMID 20680261.