Proteinska fosfataza 2
(Preusmjereno sa stranice PP2A)
| Proteinska fosfataza 2, katalitička jedinica, alfa izoforma | |
|---|---|
| Identifikatori | |
| Simbol | PPP2CA |
| Entrez | 5515 |
| Hugo | 9299 |
| OMIM | 176915 |
| RefSek | NM_002715 |
| UniProt | P67775 |
| Drugi podaci | |
| EC broj | 3.1.3.16 |
| Lokus | Hrom. 5 q23-q31 |
| Proteinska fosfataza 2, katalitička jedinica, beta izoforma | |
|---|---|
| Identifikatori | |
| Simbol | PPP2CB |
| Entrez | 5516 |
| Hugo | 9300 |
| OMIM | 176916 |
| RefSek | NM_001009552 |
| UniProt | P62714 |
| Drugi podaci | |
| EC broj | 3.1.3.16 |
| Lokus | Hrom. 8 p12 |
Proteinska fosfataza 2 (PP2), takođe poznata kao PP2A, je enzim koji je kod ljudi kodiran PPP2CA genom.[1] PP2A heterotrimerna proteinska fosfataza, je široko zastupljena i konservirana serin/treoninska fosfataza sa širokom supstratnom specifičnošću i različitim ćelijskim funkcijama. Među PP2A metama su proteini onkogene signalne kaskade, poput Raf, MEK, i AKT.
- ↑ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (1993). „Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively”. Cytogenet. Cell Genet. 63 (1): 35–41. DOI:10.1159/000133497. PMID 8383590.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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- Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y (December 2006). „Structure of the protein phosphatase 2A holoenzyme”. Cell 127 (6): 1239–51. DOI:10.1016/j.cell.2006.11.033. PMID 17174897.
- Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (October 2006). „Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins”. Cell 127 (2): 341–53. DOI:10.1016/j.cell.2006.09.025. PMID 17055435.
- Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (August 2003). „Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites”. Curr. Biol. 13 (16): 1356–64. DOI:10.1016/S0960-9822(03)00535-9. PMID 12932319.