Vitamin B2

Vitamin B2
	7,8-dimethyl- 10-((2R,3R,4S)- 2,3,4,5- tetrahydroxypentyl) benzo [g] pteridine- 2,4 (3H,10H)- dione
Identifikacija
CAS registarski broj	83-88-5
PubChem	493570
ChemSpider	431981
UNII	TLM2976OFR
MeSH	Riboflavin
ChEMBL	CHEMBL1534
Jmol-3D slike	Slika 1
SMILES
	O=C2/N=C\1/N(c3cc(c(cc3/N=C/1C(=O)N2)C)C)C[C@H](O)[C@H](O)[C@H](O)CO
InChI
	InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1 ; Kod: AUNGANRZJHBGPY-SCRDCRAPSA-N InChI=1/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1; Kod: AUNGANRZJHBGPY-SCRDCRAPBG InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1; Kod: AUNGANRZJHBGPY-SCRDCRAPSA-N
Svojstva
Molekulska formula	C17H20N4O6
Molarna masa	376.36 g/mol
Tačka topljenja	290 °C (razlaže se)
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Vitamin B2 ili riboflavin je vitamin B-kompleksa koji se primjenjuje u obliku soli topljivih u vodi. Često ga nazivaju i faktorom rasta odnosno disanja stanica. Uključen je u metaboličke procese cijeloga tijela te je neophodan u iskorištavanju energije iz hrane.

Riboflavin je naračastožuti prašak gorka okusa. Slabo se topi u vodi, a otopina je žute boje. Strukturno gledajući čine ga aloksazinska jezgra i ugljikohidrat riboza. Aktivni je sastojak dva koenzima: FMN - flavin-mononukleotida (čine ga riboflavin i fosfat) i FAD – flavin–adenin-dinukleotida (čine ga riboflavin, dva fosfata i adenin).

Bogat izvor vitamina B2 su jetra, bubreg, riba, jaja, mlijeko, sir, kvasac, zeleno povrće te neoljuštene žitarice.^[5]^[6] Do gubitka ovog vitamina može doći izlaganjem na suncu te kuhanjem. Preporučene dnevne količine (RDA) za odraslu zdravu ženu su od 1.2 - 1.3 mg, a za zdravog muškarca su od 1.4 - 1.7 mg.

Ovaj vitamin također igra važnu ulogu u metabolizmu preko svojih koenzima FMN i FAD. Hipovitaminoza nastaje najčešće nedovoljnim unosom hrane pa može doći do problema sa vezivnim tkivom, noktima i vidom.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Manthey KC, Rodriguez-Melendez R, Hoi JT, Zempleni J (April 2006). „Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle”. J. Nutr. Biochem. 17 (4): 250–6. DOI:10.1016/j.jnutbio.2005.05.004. PMC 1407763. PMID 16109485.
↑ R. Lakshmi, A. V. Lakshmi and M. S. Bamji. „Mechanism of impaired skin collagen maturity in riboflavin or pyridoxine deficiency”. Journal of Biosciences (4): 289-295. DOI:10.1007/BF02702670.

Povezano

Vitamin B1 (Tiamin)
Vitamin B2 (Riboflavin)
Vitamin B3(Nikotinamid)
Vitamin B5 (Pantotenska kiselina)
Vitamin B6 (Piridoksin)
Vitamin B9 (Folna kiselina)
Vitamin B12 (Cijanokobalamin)
Vitamin H (Biotin)
E101

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Manthey KC, Rodriguez-Melendez R, Hoi JT, Zempleni J (April 2006). „Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle”. J. Nutr. Biochem. 17 (4): 250–6. DOI:10.1016/j.jnutbio.2005.05.004. PMC 1407763. PMID 16109485.

[6] R. Lakshmi, A. V. Lakshmi and M. S. Bamji. „Mechanism of impaired skin collagen maturity in riboflavin or pyridoxine deficiency”. Journal of Biosciences (4): 289-295. DOI:10.1007/BF02702670.

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