Interstate 381

I-381
Route information
Length	1.70 mi (2.74 km)
Existed	1960–present
History	I-381 designated in 1961
NHS	Entire route
Major junctions
South end	SR 381 in Bristol
North end	I-81 / US 58 in Bristol
Location
Country	United States
State	Virginia
Highway system
Interstate Highway System Main Auxiliary Suffixed Business Future Virginia Routes Interstate US Primary Secondary Byways History HOT lanes
← SR 380 SR 382 →

Interstate 381 (I-381) is an auxiliary Interstate in the U.S. state of Virginia. It is a spur from I-81 that provides access to Bristol. It runs for 1.7 miles (2.7 km) from the intersection of Commonwealth Avenue (SR 381) and Keys/Church Streets in Bristol north to I-81.