2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza
| 2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.10 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza (EC 2.2.1.10, ADH sintaza, ADHS, MJ0400 (gen)) je enzim sa sistematskim imenom L-aspartat 4-semialdehid:1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat metilglioksaltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-aspartat 4-semialdehid + 1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat 2-amino-3,7-didezoksi-D-treo-hept-6-ulosonat + 2,3-dioksopropil fosfat
Ovaj enzim ima ključnu ulogu u alternativnoj biosintezi 3-dehidrohinata (DHQ), koji učestvuje u kanoničkoj biosintezi aromatičnnih aminokiselina.
Reference
[уреди | уреди извор]- ^ White, R.H. (2004). „L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii”. Biochemistry. 43: 7618—7627. PMID 15182204.
- ^ Samland, A.K., Wang, M. and Sprenger, G.A. (2008). „MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity”. FEMS Microbiol. Lett. 281: 36—41. PMID 18318840.
- ^ Morar, M., White, R.H. and Ealick, S.E. (2007). „Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids”. Biochemistry. 46: 10562—10571. PMID 17713928.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
