UGT2B10

UGT2B10
Identifikatori
Alijasi	UGT2B10
Spoljašnji ID	OMIM: 600070 MGI: 2140962 HomoloGene: 117389 GeneCards: UGT2B10
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	87,054,796 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• glycosyltransferase activity; • transferase activity; • hexosyltransferase activity; • glucuronosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • organelle membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • ендоплазматични ретикулум; • мембрана;
Biological process	• метаболизам; • липидни метаболизам;
	Sources:Amigo / QuickGO
Ortolozi
	7365
	100727
	ENSG00000275190; ENSG00000109181
	ENSMUSG00000029260
	P36537
	n/a
	NM_001290091; NM_001075; NM_001144767
	NM_153598
	NP_001066; NP_001138239; NP_001277020
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glukuronoziltransferaza 2B10 je enzim koji je kod ljudi kodiran genom UGT2B10.^[4]^[5] On je odgovoran za glukuronidaciju nikotina i kotinina.^[6]^[7]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000029260 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (јул 1993). „cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily”. Biochemical and Biophysical Research Communications. 194 (1): 496—503. PMID 8333863. doi:10.1006/bbrc.1993.1847.
^ „Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10”.
^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (октобар 2010). „Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms”. Cancer Research. 70 (19): 7543—52. PMC 2998997 . PMID 20876810. doi:10.1158/0008-5472.CAN-09-4582.
^ Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (јануар 2015). „UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers”. Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94—104. PMC 4294984 . PMID 25277794. doi:10.1158/1055-9965.EPI-14-0804.

Literatura

Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P (март 2008). „Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines”. Pharmacogenetics and Genomics. 18 (3): 181—91. PMID 18300939. S2CID 19295110. doi:10.1097/FPC.0b013e3282f4dbdd.
Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P (октобар 2007). „Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism”. Cancer Research. 67 (19): 9024—9. PMID 17909004. doi:10.1158/0008-5472.CAN-07-2245 .
Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M (септембар 2007). „Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10”. Molecular Pharmacology. 72 (3): 761—8. PMID 17576790. S2CID 6062166. doi:10.1124/mol.107.037093.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). „Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry”. Journal of Proteome Research. 4 (6): 2070—80. PMC 1850943 . PMID 16335952. doi:10.1021/pr0502065.
Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP (новембар 2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine”. The Journal of Biological Chemistry. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200 .
Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH (март 1999). „Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus”. The Biochemical Journal. 338 ( Pt 2) (2): 489—98. PMC 1220077 . PMID 10024527. doi:10.1042/0264-6021:3380489.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (октобар 1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Maruyama K, Sugano S (јануар 1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000029260 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8333863-4] Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (јул 1993). „cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily”. Biochemical and Biophysical Research Communications. 194 (1): 496—503. PMID 8333863. doi:10.1006/bbrc.1993.1847.

[entrez-5] „Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10”.

[pmid20876810-6] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (октобар 2010). „Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms”. Cancer Research. 70 (19): 7543—52. PMC 2998997 . PMID 20876810. doi:10.1158/0008-5472.CAN-09-4582.

[pmid25277794-7] Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (јануар 2015). „UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers”. Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94—104. PMC 4294984 . PMID 25277794. doi:10.1158/1055-9965.EPI-14-0804.

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