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Mature B-Cell Non-Hodgkin Lymphoma

MedGen UID:
277345
•Concept ID:
C1334634
•
Neoplastic Process
Synonyms: Mature B-Cell Lymphoma; Mature B-Cell Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma that originates from mature B lymphocytes. Representative examples include diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMature B-Cell Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
Prognostic Factors and Treatment Outcome of Relapsing and Refractory Pediatric Mature B-cell Non-Hodgkin Lymphoma, Children's Cancer Hospital Egypt Experience.
Semary SF, Abdel Rahman H, Elkinaai N, Zaky I, Nagy N, Salem S, Hamoda A
J Pediatr Hematol Oncol 2023 Aug 1;45(6):e757-e763. Epub 2023 Jun 26 doi: 10.1097/MPH.0000000000002699. PMID: 37494612
Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: A report from the FAB/LMB 96 study group.
Cairo M, Auperin A, Perkins SL, Pinkerton R, Harrison L, Goldman S, Patte C
Br J Haematol 2018 Sep;182(6):859-869. Epub 2018 Jul 9 doi: 10.1111/bjh.15491. PMID: 29984828Free PMC Article

Recent clinical studies

Etiology

Effect of body mass index on the prognosis of children and adolescents with high-grade mature B-cell non-Hodgkin lymphoma.
Zeng C, Wei Z, Huang J, Zhu J, Sun F, Wang J, Lu S, Zhang Y, Sun X, Zhen Z
Cancer 2024 Dec 1;130(23):4109-4117. Epub 2024 Aug 22 doi: 10.1002/cncr.35536. PMID: 39174494
Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial.
Alexander S, Aupérin A, Bomken S, Csóka M, Kazanowska B, Chiang AK, Andres M, Uyttebroeck A, Burke GAA, Zsiros J, Pillon M, Bollard CM, Mussolin L, Verdu-Amoros J, Neven B, Barkauskas DA, Wheatley K, Patte C, Gross TG, Minard-Colin V; Children's Oncology Group; European Intergroup for Childhood Non-Hodgkin's Lymphoma
Lancet Haematol 2023 Jun;10(6):e445-e457. Epub 2023 Apr 21 doi: 10.1016/S2352-3026(23)00062-5. PMID: 37094596Free PMC Article
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Diagnosis

Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Patient parameters and response after administration of rituximab in pediatric mature B-cell non-Hodgkin lymphoma.
Bethke M, Varga G, Weinhage T, Sabharwal H, Mellgren K, Randau G, Rolfing M, Wittkowski H, Foell D, Michgehl U, Burkhardt B
Pediatr Blood Cancer 2022 Apr;69(4):e29514. Epub 2021 Dec 22 doi: 10.1002/pbc.29514. PMID: 34939314
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Therapy

Epcoritamab: First Approval.
Frampton JE
Drugs 2023 Sep;83(14):1331-1340. doi: 10.1007/s40265-023-01930-4. PMID: 37597091
Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Patient parameters and response after administration of rituximab in pediatric mature B-cell non-Hodgkin lymphoma.
Bethke M, Varga G, Weinhage T, Sabharwal H, Mellgren K, Randau G, Rolfing M, Wittkowski H, Foell D, Michgehl U, Burkhardt B
Pediatr Blood Cancer 2022 Apr;69(4):e29514. Epub 2021 Dec 22 doi: 10.1002/pbc.29514. PMID: 34939314
Dose escalation of subcutaneous epcoritamab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an open-label, phase 1/2 study.
Hutchings M, Mous R, Clausen MR, Johnson P, Linton KM, Chamuleau MED, Lewis DJ, Sureda Balari A, Cunningham D, Oliveri RS, Elliott B, DeMarco D, Azaryan A, Chiu C, Li T, Chen KM, Ahmadi T, Lugtenburg PJ
Lancet 2021 Sep 25;398(10306):1157-1169. Epub 2021 Sep 8 doi: 10.1016/S0140-6736(21)00889-8. PMID: 34508654
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Prognosis

Effect of body mass index on the prognosis of children and adolescents with high-grade mature B-cell non-Hodgkin lymphoma.
Zeng C, Wei Z, Huang J, Zhu J, Sun F, Wang J, Lu S, Zhang Y, Sun X, Zhen Z
Cancer 2024 Dec 1;130(23):4109-4117. Epub 2024 Aug 22 doi: 10.1002/cncr.35536. PMID: 39174494
Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Burkitt lymphoma and atypical Burkitt or Burkitt-like lymphoma: should these be treated as different diseases?
Thomas DA, O'Brien S, Faderl S, Manning JT Jr, Romaguera J, Fayad L, Hagemeister F, Medeiros J, Cortes J, Kantarjian H
Curr Hematol Malig Rep 2011 Mar;6(1):58-66. doi: 10.1007/s11899-010-0076-4. PMID: 21191675Free PMC Article

Clinical prediction guides

Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
No increased risk of mature B-cell non-Hodgkin lymphoma after Q fever detected: results from a 16-year ecological analysis of the Dutch population incorporating the 2007-2010 Q fever outbreak.
Weehuizen JM, van Roeden SE, Hogewoning SJ, van der Hoek W, Bonten MJM, Hoepelman AIM, Bleeker-Rovers CP, Wever PC, Oosterheert JJ
Int J Epidemiol 2022 Oct 13;51(5):1481-1488. doi: 10.1093/ije/dyac053. PMID: 35352121Free PMC Article
Dose escalation of subcutaneous epcoritamab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an open-label, phase 1/2 study.
Hutchings M, Mous R, Clausen MR, Johnson P, Linton KM, Chamuleau MED, Lewis DJ, Sureda Balari A, Cunningham D, Oliveri RS, Elliott B, DeMarco D, Azaryan A, Chiu C, Li T, Chen KM, Ahmadi T, Lugtenburg PJ
Lancet 2021 Sep 25;398(10306):1157-1169. Epub 2021 Sep 8 doi: 10.1016/S0140-6736(21)00889-8. PMID: 34508654
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

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