Hyperpolarization-activated, cyclic nucleotide-gated K+ 2 (Q21982207)

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mammalian protein found in Mus musculus

brain cyclic nucleotide-gated channel 2
hyperpolarization-activated cation channel 1
BCNG-2
HAC-1
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Hcn2

Language	Label	Description	Also known as
English	Hyperpolarization-activated, cyclic nucleotide-gated K+ 2	mammalian protein found in Mus musculus	brain cyclic nucleotide-gated channel 2 hyperpolarization-activated cation channel 1 BCNG-2 HAC-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Hcn2

Statements

1 reference

25 May 2022

UniProt protein ID

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

0 references

RmlC-like jelly roll fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Potassium channel, voltage-dependent, EAG/ELK/ERG

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Cyclic nucleotide-binding-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

potassium channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

sodium channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

voltage-gated ion channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

ion channel activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

intracellular cAMP-activated cation channel activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

voltage-gated potassium channel activity

determination method or standard

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

PDZ domain binding

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

voltage-gated potassium channel activity

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

integral component of plasma membrane

determination method or standard

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88703&geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

dendrite membrane

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

somatodendritic compartment

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

dendritic shaft

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

integral component of plasma membrane

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

biological process

sodium ion transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

regulation of membrane potential

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

regulation of ion transmembrane transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

transmembrane transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

potassium ion transmembrane transport

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

cellular response to cAMP

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88703

determination method or standard

physically interacts with

adenosine cyclic phosphate

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

guanosine cyclic 3',5'-phosphate

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Ion transport N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Cyclic nucleotide-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Cyclic nucleotide-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Ion transport domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88703

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000020581

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000020581

ENSMUSP00000097113

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000097113

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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