Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases (Q24292904)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071557

Lysine demethylase 7A

1 reference

GOA release 2020-03-11

PHD finger protein 8

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methylated histone binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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John R Horton

1

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Anup K Upadhyay

2

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Hank H Qi

3

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Xing Zhang

4

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Yang Shi

5

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Xiaodong Cheng

Nature Structural & Molecular Biology

6

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language of work or name

English

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publication date

January 2010

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published in

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volume

17

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issue

1

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page(s)

38-43

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cites work

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

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CXXC domain of human DNMT1 is essential for enzymatic activity

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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

19 March 2017

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

19 March 2017

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A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

19 March 2017

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Structural basis of the recognition of a methylated histone tail by JMJD2A

19 March 2017

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The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

19 March 2017

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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

19 March 2017

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

19 March 2017

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

19 March 2017

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Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

19 March 2017

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

19 March 2017

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

19 March 2017

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Translating the Histone Code

19 March 2017

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The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

19 March 2017

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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

19 March 2017

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Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

19 March 2017

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

19 March 2017

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The language of covalent histone modifications

19 March 2017

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Histone demethylation by a family of JmjC domain-containing proteins

7 April 2017

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The complex language of chromatin regulation during transcription

19 March 2017

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Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Defining an epigenetic code

7 April 2017

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Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

19 March 2017

1 reference

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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

19 March 2017

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The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA

19 March 2017

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Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

19 March 2017

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Protein production by auto-induction in high density shaking cultures

22 April 2017

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Likelihood-enhanced fast rotation functions

22 April 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

22 April 2017

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Coot: model-building tools for molecular graphics

22 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

22 April 2017

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Enhanced genome annotation using structural profiles in the program 3D-PSSM

22 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNSMB.1753

JmjC-domain-containing proteins and histone demethylation

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Chromatin signatures of pluripotent cell lines

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Genomic maps and comparative analysis of histone modifications in human and mouse

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Dot1p modulates silencing in yeast by methylation of the nucleosome core

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Crosstalk among Histone Modifications

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2849977

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNSMB.1753

Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNSMB.1753

Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation

21 January 2018

1 reference

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Cell biology: Nondisjunction, aneuploidy and tetraploidy (Reply)

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1038/NSMB.1753

1 reference

Dimensions Publication ID

1023623906

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1 reference

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PubMed publication ID

20023638

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