G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis (Q24298167)

GOA release 2020-03-11

tumor protein p53

1 reference

negative regulation of apoptotic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Xiaoqing Chen

1

Xiaoqing

Chen

1 reference

19 October 2023

Huiling Zhu

2

Huiling

Zhu

1 reference

19 October 2023

Man Yuan

3

Man

Yuan

1 reference

19 October 2023

Jie Fu

4

Jie

Fu

1 reference

19 October 2023

Yuqing Zhou

5

Yuqing

Zhou

1 reference

19 October 2023

Lan Ma

6

Lan

Ma

1 reference

Journal of Biological Chemistry

19 October 2023

language of work or name

English

0 references

publication date

23 April 2010

0 references

published in

0 references

volume

285

0 references

issue

17

0 references

page(s)

12823-30

0 references

cites work

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Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

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A role for ATR in the DNA damage-induced phosphorylation of p53

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Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation

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Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5

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Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family

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p53, the cellular gatekeeper for growth and division

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Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness

19 March 2017

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Regulation of receptor trafficking by GRKs and arrestins

19 March 2017

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

19 March 2017

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The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation

19 March 2017

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G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction

19 March 2017

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

19 March 2017

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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5

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Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

19 March 2017

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Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development

7 April 2017

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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

27 September 2017

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EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.

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p53: traffic cop at the crossroads of DNA repair and recombination

27 September 2017

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G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence

27 September 2017

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Post-translational modification of p53 in tumorigenesis

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Desensitization of G protein-coupled receptors and neuronal functions

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Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo

27 September 2017

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Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization

27 September 2017

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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

27 September 2017

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

27 September 2017

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Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

27 September 2017

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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

27 September 2017

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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

27 September 2017

1 reference

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Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases

27 September 2017

1 reference

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GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment

27 September 2017

1 reference

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Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857122

Mdm2 association with p53 targets its ubiquitination

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857122

Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C.

30 May 2018

1 reference

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Carboxyl terminus of delta opioid receptor is required for agonist-dependent receptor phosphorylation

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.094243

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.094243

Measurement of changes in apoptosis and cell cycle regulatory kinase Cdk2.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857122

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

G protein-coupled receptor kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.094243

0 references

Fatcat ID

release_ugsvioo6n5ewbg6dbcyitnpkza

0 references

PMC publication ID

2857122

0 references