RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites (Q24306789)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0070530

K6-linked polyubiquitin modification-dependent protein binding

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071796

Ubiquitin interaction motif containing 1

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BRCA1 DNA repair associated

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BRISC and BRCA1 A complex member 2

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BRCA1/BRCA2-containing complex subunit 3

1 reference

Aedín C Culhane

4

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author name string

Bijan Sobhian

1

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Genze Shao

2

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Dana R Lilli

3

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Lisa A Moreau

5

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Bing Xia

6

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David M Livingston

7

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Roger A Greenberg

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

8

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language of work or name

English

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publication date

25 May 2007

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published in

Science

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volume

316

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issue

5828

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page(s)

1198-202

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

JAMM: a metalloprotease-like zinc site in the proteasome and signalosome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

MDC1 is a mediator of the mammalian DNA damage checkpoint

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Megabase chromatin domains involved in DNA double-strand breaks in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Genomic instability in mice lacking histone H2AX

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

A proteomics approach to understanding protein ubiquitination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706583

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

27 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17525341

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1139516

1 reference

1 reference

1 reference

PubMed publication ID

17525341

1 reference