PML, a growth suppressor disrupted in acute promyelocytic leukemia (Q24324168)

2

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J H Liu

3

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G Lozano

4

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K S Chang

Molecular and Cellular Biology

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language of work or name

English

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publication date

October 1994

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published in

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volume

14

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issue

10

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page(s)

6858-67

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cites work

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Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins

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Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

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High-efficiency transformation of mammalian cells by plasmid DNA

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

19 March 2017

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Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

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Identification of a receptor for the morphogen retinoic acid

19 March 2017

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All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results

19 March 2017

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Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

19 March 2017

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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

19 March 2017

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A novel cysteine-rich sequence motif

19 March 2017

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

19 March 2017

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

19 March 2017

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

7 April 2017

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A versatile in vivo and in vitro eukaryotic expression vector for protein engineering

7 April 2017

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Improved retroviral vectors for gene transfer and expression

7 April 2017

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The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1

7 April 2017

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PML protein expression in hematopoietic and acute promyelocytic leukemia cells

27 September 2017

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A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage

27 September 2017

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PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection

27 September 2017

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Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts

27 September 2017

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Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

27 September 2017

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Retroviral vectors for introduction of genes into mammalian cells.

27 September 2017

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Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene

27 September 2017

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A safe packaging line for gene transfer: separating viral genes on two different plasmids

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Systemic effects of vitamin D.

27 September 2017

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The p53 proto-oncogene can act as a suppressor of transformation

27 September 2017

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All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship.

27 September 2017

1 reference

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TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

27 September 2017

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Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Leukemia and the disruption of normal hematopoiesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Cooperation between oncogenes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Wild-type p53 can down-modulate the activity of various promoters

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Characterization of a Fusion cDNA (RARA/myl) Transcribed from the t(15;17) Translocation Breakpoint in Acute Promyelocytic Leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

1α,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60)

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Negative regulation of human c-fos expression by the retinoblastoma gene product

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

30 May 2018

1 reference

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Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia

30 May 2018

1 reference

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Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

8 Use of glutaraldehyde as a coupling agent for proteins and peptides

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359216

Frequency of RAS and p53 mutations in acute promyelocytic leukemias

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia

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https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Gene expression in mice after high efficiency retroviral-mediated gene transfer

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https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

The beta actin promoter. High levels of transcription depend upon a CCAAT binding factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

The t(15;17) breakpoint in acute promyelocytic leukemia cluster within two different sites of the myl gene: targets for the detection of minimal residual disease by the polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Cytogenetic studies in acute promyelocytic leukemia: a survey of secondary chromosomal abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020

Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7935403

12 December 2020