Foxp3 protein stability is regulated by cyclin-dependent kinase 2 (Q28117202)

4 January 2017

title

Foxp3 protein stability is regulated by cyclin-dependent kinase 2 (English)

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4 January 2017

Peter A. Morawski

1

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4 January 2017

Parul Mehra

2

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4 January 2017

Chunxia Chen

3

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4 January 2017

Tricia Bhatti

4

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4 January 2017

Andrew D. Wells

5

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4 January 2017

language of work or name

English

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publication date

23 August 2013

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Journal of Biological Chemistry

4 January 2017

published in

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4 January 2017

volume

288

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4 January 2017

issue

34

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4 January 2017

page(s)

24494–24502

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Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

4 January 2017

cites work

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FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

20 March 2017

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Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

20 March 2017

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

20 March 2017

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Control of regulatory T cell development by the transcription factor Foxp3

20 March 2017

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

20 March 2017

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Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

20 March 2017

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Cdk2 knockout mice are viable

20 March 2017

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20 March 2017

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

20 March 2017

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Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

20 March 2017

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Production of high-titer helper-free retroviruses by transient transfection

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Ubiquitin ligases: cell-cycle control and cancer

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

7 April 2017

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Cyclin-dependent kinase 2 controls peripheral immune tolerance

7 April 2017

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Cyclin-dependent kinase modulators and cancer therapy

29 September 2017

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First insight into the kinome of human regulatory T cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.

29 September 2017

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Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

29 September 2017

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The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD

29 September 2017

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TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

29 September 2017

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The age of crosstalk: phosphorylation, ubiquitination, and beyond

29 September 2017

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Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.

29 September 2017

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

29 September 2017

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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

29 September 2017

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Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response

29 September 2017

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

29 September 2017

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

29 September 2017

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Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells

29 September 2017

1 reference

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Stability of the regulatory T cell lineage in vivo.

2 June 2018

1 reference

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Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4+ T cell effector function

2 June 2018

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Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function

21 January 2018

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Cdc2-cyclin E complexes regulate the G1/S phase transition

21 January 2018

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

21 January 2018

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Expression of the murine homologue of the cell cycle control protein p34cdc2 in T lymphocytes

21 January 2018

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Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes

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Inhibition of the Melanoma Cell Cycle and Regulation at the G1/S Transition by 12-O-Tetradecanoylphorbol-13-acetate (TPA) by Modulation of CDK2 Activity

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Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients

1 reference

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Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis

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TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells

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Cdk1: the dominant sibling of Cdk2

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Identifiers

DOI

10.1074/JBC.M113.467704

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PMC publication ID

3750148

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1 reference