hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response (Q28139139)

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A L Brown

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C H Lee

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J H Chung

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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language of work or name

English

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publication date

9 March 2000

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published in

Nature

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volume

404

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issue

6774

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page(s)

201-4

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cites work

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BRCA1 required for transcription-coupled repair of oxidative DNA damage

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

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BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair

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Brca1 controls homology-directed DNA repair

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

21 January 2018

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

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A kinase from fission yeast responsible for blocking mitosis in S phase

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

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Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae

21 January 2018

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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

21 January 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

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Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

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Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

21 January 2018

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