All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. (Q55071162)

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27 March 2020

title

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS (English)

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amyotrophic lateral sclerosis

27 March 2020

main subject

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1 reference

3

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9

Kevin Eggan

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Adam E Cohen

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27 March 2020

author name string

Evangelos Kiskinis

1

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27 March 2020

Joel M Kralj

2

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27 March 2020

Eli N Weinstein

4

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27 March 2020

Hongkang Zhang

5

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Konstantinos Tsioras

6

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27 March 2020

Ole Wiskow

7

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J Alberto Ortega

8

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27 March 2020

publication date

17 May 2018

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27 March 2020

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27 March 2020

volume

10

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issue

6

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page(s)

1991-2004

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Optogenetic Approaches to Drug Discovery in Neuroscience and Beyond

27 March 2020

cites work

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Probing disorders of the nervous system using reprogramming approaches

18 June 2018

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Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study

18 June 2018

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Improving and accelerating drug development for nervous system disorders

18 June 2018

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Dimensionality reduction for large-scale neural recordings

18 June 2018

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Automatic parameter estimation of multicompartmental neuron models via minimization of trace error with control adjustment

18 June 2018

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All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

18 June 2018

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Bringing bioelectricity to light

18 June 2018

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Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

18 June 2018

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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

18 June 2018

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Temporal dynamics of microbial rhodopsin fluorescence reports absolute membrane voltage

18 June 2018

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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

18 June 2018

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Flash memory: photochemical imprinting of neuronal action potentials onto a microbial rhodopsin.

18 June 2018

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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

18 June 2018

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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

18 June 2018

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Optical recording of action potentials in mammalian neurons using a microbial rhodopsin

18 June 2018

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Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study

18 June 2018

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Constructing and deconstructing stem cell models of neurological disease

18 June 2018

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A functionally characterized test set of human induced pluripotent stem cells

18 June 2018

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Automated analysis of cellular signals from large-scale calcium imaging data

18 June 2018

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PIP2 is a necessary cofactor for ion channel function: how and why?

18 June 2018

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Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing

18 June 2018

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Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage

18 June 2018

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Pathways modulating neural KCNQ/M (Kv7) potassium channels

18 June 2018

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The dynamic clamp comes of age.

18 June 2018

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Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation

18 June 2018

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From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

13 August 2018

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A hierarchical structure of cortical interneuron electrical diversity revealed by automated statistical analysis

13 August 2018

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Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons.

13 August 2018

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Electrical properties of motoneurons in the spinal cord of rat embryos.

13 August 2018

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Protein HU binds specifically to kinked DNA

13 August 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/29779896

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Calcium/calmodulin-dependent protein kinase II expression in motor neurons: effect of axotomy

1 reference

PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STEMCR.2018.04.020

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27 March 2020

1 reference

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27 March 2020

PubMed publication ID

29779896

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