那呐妥单抗
| 单克隆抗体 | |
|---|---|
| 种类 | 完整抗体 |
| 目標 | RON |
| 臨床資料 | |
| ATC碼 |
|
| 识别信息 | |
| CAS号 | 1188275-92-4  |
| ChemSpider |
|
| UNII | |
| KEGG | |
| 化学信息 | |
| 化学式 | C6454H10026N1754O2020S44 |
| 摩尔质量 | 145,922.10 g·mol−1 |
那呐妥单抗（INN：Narnatumab；开发代号：IMC-RON8、LY3012219）[1]是一种针对RON受体的人单克隆抗体，设计用于治疗直肠癌和由淋巴管生成引起的实体瘤。[2]该药物目前已经进行了I期临床试验。[1][2][3]
那呐妥单抗由ImClone Systems开发。[4]
参考资料
[编辑]- ^ 1.0 1.1 LoRusso, Patricia M.; Gounder, Mrinal; Jalal, Shadia I.; André, Valérie; Kambhampati, Siva Rama Prasad; Loizos, Nick; Hall, Jennifer; Holzer, Timothy R.; Nasir, Aejaz; Cosaert, Jan; Kauh, John. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Investigational New Drugs. 2017-08, 35 (4) [2024-01-24]. ISSN 1573-0646. PMC 5502198
. PMID 28161886. doi:10.1007/s10637-016-0413-0. （原始内容存档于2024-01-24）.
- ^ 2.0 2.1 Saif, Muhammad Wasif; Knost, James A.; Chiorean, E. Gabriela; Kambhampati, Siva Rama Prasad; Yu, Danni; Pytowski, Bronislaw; Qin, Amy; Kauh, John S.; O'Neil, Bert H. Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 2016-10, 78 (4) [2024-01-24]. ISSN 1432-0843. PMID 27566701. doi:10.1007/s00280-016-3134-3. （原始内容存档于2024-03-22）.
- ^ Yu Koh, Xin; Koh, Xin Yu; Xiao Hui Koh; Spiegelberg, Diana; Jha, Preeti; Nestor, Marika; Hwang, Le-ann; Tan, Ban Xiong; Lane, David Philip. Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy. Scientific Reports. 2022-12-29, 12 (1) [2024-01-24]. ISSN 2045-2322. doi:10.1038/s41598-022-26404-7. （原始内容存档于2024-01-24） （英语）.
- ^ Narnatumumab. AdisInsight. [31 January 2017]. （原始内容存档于2024-01-24）.
