A2058

A2058 （亦稱ATCC CRL-11147）是人類惡性黑色素瘤細胞系，最初分離自一位43歲的人類男性轉移性腦癌（英语：Brain metastasis）患者^[1]。A2058細胞具有高度移動特性，並且表達神經生長因子（英语：Nerve growth factor）^[2]及神經生長因子受體^[3]。高度醣基化的CD93跨膜蛋白分佈在A2058細胞的細胞膜，尤其在細胞與細胞接觸的位置，其延展面積比載體控制細胞為大，並且促進細胞間緊密的接觸，故而加入CD93抗體及耗盡細胞培養基中的鈣離子會破壞以CD93蛋白作為媒介的A2058細胞貼附^[4]。有研究指出蜜蜂蜂毒會誘發A2058細胞的凋亡，短時間內便可令胞體外與內質網的鈣離子進入細胞內，所以鈣離子在細胞內的濃度會快速上升^[5]。

參考資料

^ Todaro, GJ; Fryling, C; De Larco, JE. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.. Proceedings of the National Academy of Sciences of the United States of America. 1980-09, 77 (9): 5258–62 [2019-12-06]. PMID 6254071. doi:10.1073/pnas.77.9.5258.
^ Fabricant, RN; De Larco, JE; Todaro, GJ. Nerve growth factor receptors on human melanoma cells in culture.. Proceedings of the National Academy of Sciences of the United States of America. 1977-02, 74 (2): 565–9 [2019-12-06]. PMID 265522. doi:10.1073/pnas.74.2.565.
^ Sherwin, SA; Sliski, AH; Todaro, GJ. Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.. Proceedings of the National Academy of Sciences of the United States of America. 1979-03, 76 (3): 1288–92 [2019-12-06]. PMID 375235. doi:10.1073/pnas.76.3.1288.
^ CHEN Hu-yan, WANG Shang-shang, JIANG Min, ZHANG Qiao-an, CHEN Lian-jun. Inhibitory effect of microRNA-205 on migration and invasion of melanoma cell lines and its related mechanism. Academic Journal of Second Military Medical University, 2017, 38(5): 576-82 [2019-12-06]
^ Tu, WC; Wu, CC; Hsieh, HL; Chen, CY; Hsu, SL. Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells.. Toxicon : official journal of the International Society on Toxinology. 2008-08-01, 52 (2): 318–29 [2019-12-06]. PMID 18602939. doi:10.1016/j.toxicon.2008.06.007.

外部連結

Cellosaurus entry for A2058（页面存档备份，存于互联网档案馆）

[1] Todaro, GJ; Fryling, C; De Larco, JE. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.. Proceedings of the National Academy of Sciences of the United States of America. 1980-09, 77 (9): 5258–62 [2019-12-06]. PMID 6254071. doi:10.1073/pnas.77.9.5258.

[2] Fabricant, RN; De Larco, JE; Todaro, GJ. Nerve growth factor receptors on human melanoma cells in culture.. Proceedings of the National Academy of Sciences of the United States of America. 1977-02, 74 (2): 565–9 [2019-12-06]. PMID 265522. doi:10.1073/pnas.74.2.565.

[3] Sherwin, SA; Sliski, AH; Todaro, GJ. Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.. Proceedings of the National Academy of Sciences of the United States of America. 1979-03, 76 (3): 1288–92 [2019-12-06]. PMID 375235. doi:10.1073/pnas.76.3.1288.

[4] CHEN Hu-yan, WANG Shang-shang, JIANG Min, ZHANG Qiao-an, CHEN Lian-jun. Inhibitory effect of microRNA-205 on migration and invasion of melanoma cell lines and its related mechanism. Academic Journal of Second Military Medical University, 2017, 38(5): 576-82 [2019-12-06]

[5] Tu, WC; Wu, CC; Hsieh, HL; Chen, CY; Hsu, SL. Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells.. Toxicon : official journal of the International Society on Toxinology. 2008-08-01, 52 (2): 318–29 [2019-12-06]. PMID 18602939. doi:10.1016/j.toxicon.2008.06.007.

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