Transformation related protein 53 binding protein 1 (Q21992210)

http://www.ebi.ac.uk/interpro/protein/P70399

Ribosomal protein L2, domain 2

1 reference

http://www.ebi.ac.uk/interpro/protein/P70399

Tumour suppressor p53-binding protein-1 Tudor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

BRCT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

1 reference

14 February 2019

sequence-specific DNA binding

1 reference

14 February 2019

The histone methyltransferase MMSET regulates class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

telomeric DNA binding

1 reference

14 February 2019

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

transcription factor binding

1 reference

14 February 2019

p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

damaged DNA binding

1 reference

14 February 2019

Genomic instability in mice lacking histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

protein binding

4 references

14 February 2019

53BP1 regulates DSB repair using Rif1 to control 5' end resection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

transcription coregulator activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

methylated histone binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

ubiquitin modification-dependent histone binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

transcription coregulator activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

histone binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

cell component

DNA repair complex

1 reference

14 February 2019

The histone demethylase LSD1/KDM1A promotes the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

replication fork

1 reference

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

1 reference

14 February 2019

chromosome, centromeric region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

1 reference

14 February 2019

nucleus

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

16 July 2018

Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

site of double-strand break

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

nuclear body

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

regulation of transcription, DNA-templated

biological process

p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition

2 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

16 July 2018

DNA damage checkpoint signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70399&geneProductId=UniProtKB:P70399

1 reference

16 July 2018

cellular response to DNA damage stimulus

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

double-strand break repair via nonhomologous end joining

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

ISO

14 February 2019

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

positive regulation of isotype switching

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

ISO

14 February 2019

53BP1 is required for class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

IMP

14 February 2019

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

protein homooligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

cellular response to X-ray

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

negative regulation of double-strand break repair via homologous recombination

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

ISO

14 February 2019

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

14 February 2019

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

regulation of transcription, DNA-templated

1 reference

14 February 2019

p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70399

Tumour suppressor p53-binding protein-1 Tudor domain

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/P70399

BRCT domain

1 reference