53BP1 is required for class switch recombination (Q29465541)

18 April 2017

title

53BP1 is required for class switch recombination (English)

1 reference

Transformation related protein 53 binding protein 1

18 April 2017

main subject

1 reference

GOA release 2020-03-11

author

Michel C. Nussenzweig

11

object named as

Michel C Nussenzweig

1 reference

Bernardo Reina San-Martin

18 April 2017

2

object named as

Bernardo Reina-San-Martin

1 reference

18 April 2017

Irene M Ward

1

1 reference

18 April 2017

Alexandru Olaru

3

1 reference

18 April 2017

Kay Minn

4

1 reference

18 April 2017

Koji Tamada

5

1 reference

18 April 2017

Julie S Lau

6

1 reference

18 April 2017

Marilia Cascalho

7

1 reference

18 April 2017

Lieping Chen

8

1 reference

18 April 2017

Andre Nussenzweig

9

1 reference

18 April 2017

Ferenc Livak

10

1 reference

18 April 2017

Junjie Chen

12

1 reference

18 April 2017

language of work or name

English

0 references

publication date

1 May 2004

1 reference

18 April 2017

number of pages

6

1 reference

inferred from page(s)

published in

Journal of Cell Biology

1 reference

18 April 2017

volume

165

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18 April 2017

issue

4

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18 April 2017

page(s)

459-464

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Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

18 April 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Genomic instability in mice lacking histone H2AX

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

DNA double-strand breaks: signaling, repair and the cancer connection

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

18 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

21 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

AID mediates hypermutation by deaminating single stranded DNA.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

53BP1, a mediator of the DNA damage checkpoint

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

V(D)J recombination: RAG proteins, repair factors, and regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

The mechanism and regulation of chromosomal V(D)J recombination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Characterization of TCR gene rearrangements during adult murine T cell development.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Ku80 is required for immunoglobulin isotype switching

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Cell-cycle regulation of mammalian DNA double-strand-break repair

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

DNA sequences at immunoglobulin switch region recombination sites

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Circular DNA is excised by immunoglobulin class switch recombination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

Circular DNA is a product of the immunoglobulin class switch rearrangement

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172356

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

3 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15159415

12 December 2020

inferred from PubMed ID database lookup

Checkpoint signalling: focusing on 53BP1.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15159415

12 December 2020

inferred from PubMed ID database lookup

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15159415

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1083/JCB.200403021

1 reference

1 reference

1 reference

1 reference