The ARF/p53 pathway (Q33840421)

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Language	Label	Description	Also known as
English	The ARF/p53 pathway	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

Europe PubMed Central

The ARF/p53 pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

C J Sherr

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

J D Weber

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

1 February 2000

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Current Opinion in Genetics & Development

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Europe PubMed Central

PubMed publication ID

29 July 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

94-99

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p53, the cellular gatekeeper for growth and division

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor surveillance via the ARF-p53 pathway.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The INK4A/ARF locus and its two gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

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Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

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Extension of life-span by introduction of telomerase into normal human cells

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900038-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0959-437X(99)00038-6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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