Cyclin a-CDK phosphorylation regulates MDM2 protein interactions (Q42828875)

8 November 2017

title

Cyclin a-CDK phosphorylation regulates MDM2 protein interactions (English)

1 reference

8 November 2017

1 reference

T Zhang

1

1 reference

8 November 2017

C Prives

series ordinal

2

1 reference

8 November 2017

language of work or name

English

0 references

publication date

18 May 2001

1 reference

Journal of Biological Chemistry

8 November 2017

published in

1 reference

8 November 2017

volume

276

1 reference

8 November 2017

issue

32

1 reference

8 November 2017

page(s)

29702-29710

1 reference

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

8 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

p53-independent role of MDM2 in TGF-beta1 resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

G1 phase progression: cycling on cue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cyclin ubiquitination: the destructive end of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Regulating S phase: CDKs, licensing and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Human cyclin A is required for mitosis until mid prophase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Identification of a CK2 phosphorylation site in mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin-dependent kinases. Cyclin-substrate interactions dictate the efficiency of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Specific regulation of E2F family members by cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cyclin-dependent kinases: inhibition and substrate recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Evolving ideas about cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Molecular characterization of the hdm2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Stoichiometry of cyclin A-cyclin-dependent kinase 2 inhibition by p21Cip1/Waf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011326200

21 January 2018

Identifiers

DOI

10.1074/JBC.M011326200

1 reference

8 November 2017

1 reference