CDX1: الفرق بين النسختين

CDX1
معرفات
أسماء بديلة	CDX1, caudal type homeobox 1, Homeobox protein CDX-1
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600746 MGI: MGI:88360 HomoloGene: 1366 GeneCards: 1044
علم الوجود الجيني
وظائف جزيئية	• ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • ربط دي إن إي; • sequence-specific DNA binding; • ‏GO:0001077، ‏GO:0001212، ‏GO:0001213، ‏GO:0001211، ‏GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • methyl-CpG binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
مكونات خلوية	• نواة;
عمليات حيوية	• تشكل العضو الحيواني; • نمو متعدد الخلايا; • pattern specification process; • bone morphogenesis; • تمايز خلوي; • anterior/posterior axis specification; • ‏GO:0009373 ضبط نسخ الدنا; • regulation of somitogenesis; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • نقل شاردة الكالسيوم; • transcription by RNA polymerase II; • نسخ الدنا; • ‏GO:0044324، ‏GO:0003256، ‏GO:1901213، ‏GO:0046019، ‏GO:0046020، ‏GO:1900094، ‏GO:0061216، ‏GO:0060994، ‏GO:1902064، ‏GO:0003258، ‏GO:0072212 ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	P47902
	P18111
	NM_001804
	NM_009880
	NP_001795
	NP_034010
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

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مرئينص الويكي

مضمن

نسخة 02:51، 28 أغسطس 2018

CDX1‏ (Caudal type homeobox 1) هوَ بروتين يُشَفر بواسطة جين CDX1 في الإنسان.^[1]^[2]^[3]^[4]

الوظيفة

الأهمية السريرية

المراجع

^ Barker N، van Es JH، Kuipers J، Kujala P، van den Born M، Cozijnsen M، Haegebarth A، Korving J، Begthel H، Peters PJ، Clevers H (أكتوبر 2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. ج. 449 ع. 7165: 1003–7. DOI:10.1038/nature06196. PMID:17934449.
^ "Entrez Gene: CDX1 caudal type homeobox transcription factor 1".
^ Grainger S، Hryniuk A، Lohnes D (2013). "Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine". PLoS One. ج. 8 ع. 1: e54757. DOI:10.1371/journal.pone.0054757. PMC:3559873. PMID:23382958.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
^ Bonner CA، Loftus SK، Wasmuth JJ (يوليو 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. ج. 28 ع. 2: 206–11. DOI:10.1006/geno.1995.1132. PMID:8530027.

قراءة متعمقة

"Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group". Nature Genetics. ج. 12 ع. 2: 130–6. فبراير 1996. DOI:10.1038/ng0296-130. PMID:8563749.
Mallo GV، Rechreche H، Frigerio JM، Rocha D، Zweibaum A، Lacasa M، Jordan BR، Dusetti NJ، Dagorn JC، Iovanna JL (فبراير 1997). "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis". International Journal of Cancer. ج. 74 ع. 1: 35–44. DOI:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1. PMID:9036867.
Mizoshita T، Inada K، Tsukamoto T، Kodera Y، Yamamura Y، Hirai T، Kato T، Joh T، Itoh M، Tatematsu M (2002). "Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer. ج. 4 ع. 4: 185–91. DOI:10.1007/PL00011741. PMID:11846061.
Suh ER، Ha CS، Rankin EB، Toyota M، Traber PG (سبتمبر 2002). "DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry. ج. 277 ع. 39: 35795–800. DOI:10.1074/jbc.M205567200. PMID:12124393.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Domon-Dell C، Schneider A، Moucadel V، Guerin E، Guenot D، Aguillon S، Duluc I، Martin E، Iovanna J، Launay JF، Duclos B، Chenard MP، Meyer C، Oudet P، Kedinger M، Gaub MP، Freund JN (سبتمبر 2003). "Cdx1 homeobox gene during human colon cancer progression". Oncogene. ج. 22 ع. 39: 7913–21. DOI:10.1038/sj.onc.1206756. PMID:12970739.
Wong NA، Britton MP، Choi GS، Stanton TK، Bicknell DC، Wilding JL، Bodmer WF (يناير 2004). "Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proceedings of the National Academy of Sciences of the United States of America. ج. 101 ع. 2: 574–9. DOI:10.1073/pnas.0307190101. PMC:327189. PMID:14704280.
Rankin EB، Xu W، Silberg DG، Suh E (مايو 2004). "Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine". American Journal of Physiology. Gastrointestinal and Liver Physiology. ج. 286 ع. 5: G872-80. DOI:10.1152/ajpgi.00326.2003. PMID:14715525.
Béland M، Pilon N، Houle M، Oh K، Sylvestre JR، Prinos P، Lohnes D (يونيو 2004). "Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex". Molecular and Cellular Biology. ج. 24 ع. 11: 5028–38. DOI:10.1128/MCB.24.11.5028-5038.2004. PMC:416402. PMID:15143193.
Guo RJ، Huang E، Ezaki T، Patel N، Sinclair K، Wu J، Klein P، Suh ER، Lynch JP (أغسطس 2004). "Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity". The Journal of Biological Chemistry. ج. 279 ع. 35: 36865–75. DOI:10.1074/jbc.M405213200. PMID:15215241.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Alkhoury F، Malo MS، Mozumder M، Mostafa G، Hodin RA (أغسطس 2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". American Journal of Physiology. Gastrointestinal and Liver Physiology. ج. 289 ع. 2: G285-90. DOI:10.1152/ajpgi.00037.2005. PMID:15774940.
Wong NA، Wilding J، Bartlett S، Liu Y، Warren BF، Piris J، Maynard N، Marshall R، Bodmer WF (مايو 2005). "CDX1 is an important molecular mediator of Barrett's metaplasia". Proceedings of the National Academy of Sciences of the United States of America. ج. 102 ع. 21: 7565–70. DOI:10.1073/pnas.0502031102. PMC:1140438. PMID:15894614.

[pmid17934449-1] Barker N، van Es JH، Kuipers J، Kujala P، van den Born M، Cozijnsen M، Haegebarth A، Korving J، Begthel H، Peters PJ، Clevers H (أكتوبر 2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. ج. 449 ع. 7165: 1003–7. DOI:10.1038/nature06196. PMID:17934449.

[entrez-2] "Entrez Gene: CDX1 caudal type homeobox transcription factor 1".

[pmid23382958-3] Grainger S، Hryniuk A، Lohnes D (2013). "Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine". PLoS One. ج. 8 ع. 1: e54757. DOI:10.1371/journal.pone.0054757. PMC:3559873. PMID:23382958.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)

[pmid8530027-4] Bonner CA، Loftus SK، Wasmuth JJ (يوليو 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. ج. 28 ع. 2: 206–11. DOI:10.1006/geno.1995.1132. PMID:8530027.

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@@ سطر 1: / سطر 1: @@
 {{صندوق معلومات جين}}
-'''CDX1'''{{فاصل}} ('''Caudal type homeobox 1''') هوَ [[بروتين]] [[منطقة مشفرة|يُشَفر]] بواسطة [[جين]] CDX1 في [[إنسان|الإنسان]].<ref name="pmid17934449">{{cite journal | vauthors = Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H | title = Identification of stem cells in small intestine and colon by marker gene Lgr5 | journal = Nature | volume = 449 | issue = 7165 | pages = 1003–7 | date = October 2007 | pmid = 17934449 | doi = 10.1038/nature06196 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1044| accessdate = }}</ref><ref name="pmid23382958">{{cite journal | vauthors = Grainger S, Hryniuk A, Lohnes D | title = Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine | journal = PLoS One | volume = 8 | issue = 1 | pages = e54757 | year = 2013 | pmid = 23382958 | pmc = 3559873 | doi = 10.1371/journal.pone.0054757 }}</ref><ref name="pmid8530027">{{cite journal | vauthors = Bonner CA, Loftus SK, Wasmuth JJ | title = Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene | journal = Genomics | volume = 28 | issue = 2 | pages = 206–11 | date = July 1995 | pmid = 8530027 | pmc =  | doi = 10.1006/geno.1995.1132 }}</ref>
+'''CDX1'''{{فاصل}} ('''Caudal type homeobox 1''') هوَ [[بروتين]] [[منطقة مشفرة|يُشَفر]] بواسطة [[جين]] CDX1 في [[إنسان|الإنسان]].<ref name="pmid17934449">{{cite journal | vauthors = Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H | العنوان = Identification of stem cells in small intestine and colon by marker gene Lgr5 | journal = Nature | volume = 449 | issue = 7165 | الصفحات = 1003–7 | التاريخ = October 2007 | pmid = 17934449 | doi = 10.1038/nature06196 }}</ref><ref name="entrez">{{مرجع ويب | العنوان = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| المسار = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1044| تاريخ الوصول = }}</ref><ref name="pmid23382958">{{cite journal | vauthors = Grainger S, Hryniuk A, Lohnes D | العنوان = Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine | journal = PLoS One | volume = 8 | issue = 1 | الصفحات = e54757 | السنة = 2013 | pmid = 23382958 | pmc = 3559873 | doi = 10.1371/journal.pone.0054757 }}</ref><ref name="pmid8530027">{{cite journal | vauthors = Bonner CA, Loftus SK, Wasmuth JJ | العنوان = Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene | journal = Genomics | volume = 28 | issue = 2 | الصفحات = 206–11 | التاريخ = July 1995 | pmid = 8530027 | pmc =  | doi = 10.1006/geno.1995.1132 }}</ref>
 ==الوظيفة==
@@ سطر 12: / سطر 12: @@
 == قراءة متعمقة ==
 <div dir=ltr>
-{{refbegin | 2}}
+{{بداية المراجع | 2}}
-* {{cite journal | vauthors =  | title = Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group | journal = Nature Genetics | volume = 12 | issue = 2 | pages = 130–6 | date = February 1996 | pmid = 8563749 | doi = 10.1038/ng0296-130 }}
+* {{cite journal | vauthors =  | العنوان = Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group | journal = Nature Genetics | volume = 12 | issue = 2 | الصفحات = 130–6 | التاريخ = February 1996 | pmid = 8563749 | doi = 10.1038/ng0296-130 }}
-* {{cite journal | vauthors = Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL | title = Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis | journal = International Journal of Cancer | volume = 74 | issue = 1 | pages = 35–44 | date = February 1997 | pmid = 9036867 | doi = 10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1 }}
+* {{cite journal | vauthors = Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL | العنوان = Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis | journal = International Journal of Cancer | volume = 74 | issue = 1 | الصفحات = 35–44 | التاريخ = February 1997 | pmid = 9036867 | doi = 10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1 }}
-* {{cite journal | vauthors = Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M | title = Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach | journal = Gastric Cancer | volume = 4 | issue = 4 | pages = 185–91 | year = 2002 | pmid = 11846061 | doi = 10.1007/PL00011741 }}
+* {{cite journal | vauthors = Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M | العنوان = Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach | journal = Gastric Cancer | volume = 4 | issue = 4 | الصفحات = 185–91 | السنة = 2002 | pmid = 11846061 | doi = 10.1007/PL00011741 }}
-* {{cite journal | vauthors = Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG | title = DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 35795–800 | date = September 2002 | pmid = 12124393 | doi = 10.1074/jbc.M205567200 }}
+* {{cite journal | vauthors = Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG | العنوان = DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | الصفحات = 35795–800 | التاريخ = September 2002 | pmid = 12124393 | doi = 10.1074/jbc.M205567200 }}
-* {{cite journal | vauthors = Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN | title = Cdx1 homeobox gene during human colon cancer progression | journal = Oncogene | volume = 22 | issue = 39 | pages = 7913–21 | date = September 2003 | pmid = 12970739 | doi = 10.1038/sj.onc.1206756 }}
+* {{cite journal | vauthors = Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN | العنوان = Cdx1 homeobox gene during human colon cancer progression | journal = Oncogene | volume = 22 | issue = 39 | الصفحات = 7913–21 | التاريخ = September 2003 | pmid = 12970739 | doi = 10.1038/sj.onc.1206756 }}
-* {{cite journal | vauthors = Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL, Bodmer WF | title = Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 2 | pages = 574–9 | date = January 2004 | pmid = 14704280 | pmc = 327189 | doi = 10.1073/pnas.0307190101 }}
+* {{cite journal | vauthors = Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL, Bodmer WF | العنوان = Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 2 | الصفحات = 574–9 | التاريخ = January 2004 | pmid = 14704280 | pmc = 327189 | doi = 10.1073/pnas.0307190101 }}
-* {{cite journal | vauthors = Rankin EB, Xu W, Silberg DG, Suh E | title = Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 286 | issue = 5 | pages = G872-80 | date = May 2004 | pmid = 14715525 | doi = 10.1152/ajpgi.00326.2003 }}
+* {{cite journal | vauthors = Rankin EB, Xu W, Silberg DG, Suh E | العنوان = Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 286 | issue = 5 | الصفحات = G872-80 | التاريخ = May 2004 | pmid = 14715525 | doi = 10.1152/ajpgi.00326.2003 }}
-* {{cite journal | vauthors = Béland M, Pilon N, Houle M, Oh K, Sylvestre JR, Prinos P, Lohnes D | title = Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex | journal = Molecular and Cellular Biology | volume = 24 | issue = 11 | pages = 5028–38 | date = June 2004 | pmid = 15143193 | pmc = 416402 | doi = 10.1128/MCB.24.11.5028-5038.2004 }}
+* {{cite journal | vauthors = Béland M, Pilon N, Houle M, Oh K, Sylvestre JR, Prinos P, Lohnes D | العنوان = Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex | journal = Molecular and Cellular Biology | volume = 24 | issue = 11 | الصفحات = 5028–38 | التاريخ = June 2004 | pmid = 15143193 | pmc = 416402 | doi = 10.1128/MCB.24.11.5028-5038.2004 }}
-* {{cite journal | vauthors = Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, Klein P, Suh ER, Lynch JP | title = Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 35 | pages = 36865–75 | date = August 2004 | pmid = 15215241 | doi = 10.1074/jbc.M405213200 }}
+* {{cite journal | vauthors = Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, Klein P, Suh ER, Lynch JP | العنوان = Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 35 | الصفحات = 36865–75 | التاريخ = August 2004 | pmid = 15215241 | doi = 10.1074/jbc.M405213200 }}
-* {{cite journal | vauthors = Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA | title = Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2 | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 289 | issue = 2 | pages = G285-90 | date = August 2005 | pmid = 15774940 | doi = 10.1152/ajpgi.00037.2005 }}
+* {{cite journal | vauthors = Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA | العنوان = Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2 | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 289 | issue = 2 | الصفحات = G285-90 | التاريخ = August 2005 | pmid = 15774940 | doi = 10.1152/ajpgi.00037.2005 }}
-* {{cite journal | vauthors = Wong NA, Wilding J, Bartlett S, Liu Y, Warren BF, Piris J, Maynard N, Marshall R, Bodmer WF | title = CDX1 is an important molecular mediator of Barrett's metaplasia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | pages = 7565–70 | date = May 2005 | pmid = 15894614 | pmc = 1140438 | doi = 10.1073/pnas.0502031102 }}
+* {{cite journal | vauthors = Wong NA, Wilding J, Bartlett S, Liu Y, Warren BF, Piris J, Maynard N, Marshall R, Bodmer WF | العنوان = CDX1 is an important molecular mediator of Barrett's metaplasia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | الصفحات = 7565–70 | التاريخ = May 2005 | pmid = 15894614 | pmc = 1140438 | doi = 10.1073/pnas.0502031102 }}
+{{نهاية المراجع}}
-{{refend}}
 </div>
-{{معرفات مركب كيميائي}}
+{{معرفات كيميائية}}
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