SB-228,357

SB-228,357
IUPAC ime
	N-(3-fluoro-5-piridin-3-ilfenil)-5-metoksi-6-(trifluorometil)-2,3-dihidroindol-1-karboksamid
Identifikatori
CAS broj	181629-93-6
PubChem	CID 443390
ChemSpider	391619
UNII	5RDN2E8E97
KEGG	C11742
ChEBI	CHEBI:8979
ChEMBL	CHEMBL14276
Hemijski podaci
Formula	C22H17F4N3O2
Molarna masa	431,39 g·mol−1
	SMILES COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F; ;
	InChI InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30); Key:RRJLJKRFFRZRAF-UHFFFAOYSA-N;

SB-228357 je lek koji deluje kao antagonist 5HT_2B i 5HT_2C receptora. On proizvodi antidepresivne i anksiolitičke efekte u životinjskim modelima,^[1]^[2] i inhibira 5-HT_2B posredovanu proliferaciju srčanih fibroblasta.^[3]

Vidi još

^ Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (фебруар 1999). „Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist”. British Journal of Pharmacology. 126 (3): 572—4. PMC 1565856 . PMID 10188965. doi:10.1038/sj.bjp.0702350.
^ Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, et al. (март 2000). „Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent”. Journal of Medicinal Chemistry. 43 (6): 1123—34. PMID 10737744. doi:10.1021/jm990388c.
^ Hutcheson JD, Ryzhova LM, Setola V, Merryman WD (новембар 2012). „5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation”. Journal of Molecular and Cellular Cardiology. 53 (5): 707—14. PMC 3472096 . PMID 22940605. doi:10.1016/j.yjmcc.2012.08.012.