WAY-100635

WAY-100635
(IUPAC) ime
	N-[2-[4-(2-metoksifenil)-1-piperazinil]etil]- N-(2-piridil)cikloheksankarboksamid
Klinički podaci
Identifikatori
CAS broj	146714-97-8
ATC kod	nije dodeljen
PubChem	5684
ChEMBL	CHEMBL31354
Hemijski podaci
Formula	C25H34N4O2
Mol. masa	422,56 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 ; Key: SBPRIAGPYFYCRT-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

WAY-100,635 je piperazinski lek koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni 5-HT_1A antagonist, ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan pun agonist na D₄ receptoru.^[4]^[5]^[6] On se ponekad naziva nemim antagonistom 5-HT1A receptora.^[7] WAY-100,635 i WAY-100,135 su hemijski slični.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). „WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135”. The Journal of Pharmacology and Experimental Therapeutics 278 (2): 752–762. PMID 8768728. Arhivirano iz originala na datum 2009-02-18. Pristupljeno 2014-04-05.
↑ Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (October 2006). „WAY-100635 is a potent dopamine D4 receptor agonist”. Psychopharmacology 188 (2): 244–251. DOI:10.1007/s00213-006-0490-4. PMID 16915381. ^{[mrtav link]}
↑ Marona-Lewicka D, Nichols DE (2009). „WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation”. Behav Pharmacol 20 (1): 114–8. DOI:10.1097/FBP.0b013e3283242f1a. PMID 19179855.
↑ A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). „Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist”. Behavioural Brain Research 73 (1-2): 337–333. DOI:10.1016/0166-4328(96)00118-0. PMID 8788530.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Vesa Oikonen (2007). „Quantification of (carbonyl-¹¹C)WAY-100635 PET studies”. Turku PET center.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). „WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135”. The Journal of Pharmacology and Experimental Therapeutics 278 (2): 752–762. PMID 8768728. Arhivirano iz originala na datum 2009-02-18. Pristupljeno 2014-04-05.

[5] Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (October 2006). „WAY-100635 is a potent dopamine D4 receptor agonist”. Psychopharmacology 188 (2): 244–251. DOI:10.1007/s00213-006-0490-4. PMID 16915381. ^{[mrtav link]}

[pmid19179855-6] Marona-Lewicka D, Nichols DE (2009). „WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation”. Behav Pharmacol 20 (1): 114–8. DOI:10.1097/FBP.0b013e3283242f1a. PMID 19179855.

[7] A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). „Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist”. Behavioural Brain Research 73 (1-2): 337–333. DOI:10.1016/0166-4328(96)00118-0. PMID 8788530.

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